W
William Godolphin
Researcher at University of British Columbia
Publications - 54
Citations - 11415
William Godolphin is an academic researcher from University of British Columbia. The author has contributed to research in topics: Health care & Patient participation. The author has an hindex of 25, co-authored 53 publications receiving 10910 citations. Previous affiliations of William Godolphin include Vancouver General Hospital.
Papers
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Journal ArticleDOI
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
Dennis J. Slamon,William Godolphin,Lovell A. Jones,John A. Holt,Steven G. Wong,Duane E. Keith,Wendy J. Levin,Susan G. Stuart,Judy Udove,Axel Ullrich,Michael F. Press +10 more
TL;DR: The concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers, including breast and ovarian cancer, is supported.
Journal ArticleDOI
Framework for teaching and learning informed shared decision making.
Angela Towle,William Godolphin +1 more
TL;DR: Outcomes of care and adherence to treatment regimens improve when patients are more involved and the ethical imperative of autonomy is reflected in legal trends that require a high standard of disclosure for informed consent.
Journal Article
Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.
TL;DR: FISH is compared to Southern, Northern and Western blot analyses as well as immunohistochemistry in a large cohort of archival human breast cancer specimens and is found to be superior to all other methodologies tested in assessing formalin fixed, paraffin embedded material for HER-2/neu amplification.
Journal Article
Sensitivity of HER-2/neu Antibodies in Archival Tissue Samples: Potential Source of Error in Immunohistochemical Studies of Oncogene Expression
TL;DR: The ability of these antibodies to detect overeexpression was extremely variable, providing an important explantation for the variable overexpression rate reported in the literature.
Journal Article
Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease.
Michael F. Press,Malcolm C. Pike,Victoria R. Chazin,Gene Hung,Judith A. Udove,Mitchell Markowicz,John Danyluk,William Godolphin,Mark X. Sliwkowski,Robert W. Akita,Malcolm C. Paterson,Dennis J. Slamon +11 more
TL;DR: The purpose of this report is to address the issues surrounding this controversy and to evaluate the prognostic utility of overexpression in a carefully followed group of patients using appropriately characterized reagents and methods.