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William J. Weiss
Researcher at University of Connecticut
Publications - 2
Citations - 122
William J. Weiss is an academic researcher from University of Connecticut. The author has contributed to research in topics: Thiazepine & Reaction intermediate. The author has an hindex of 2, co-authored 2 publications receiving 115 citations.
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Journal ArticleDOI
Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates
Aranapakam M. Venkatesan,Yansong Gu,Osvaldo Dos Santos,T. Abe,Atul Agarwal,Youjun Yang,Petersen Peter J,William J. Weiss,Tarek S. Mansour,Michiyoshi Nukaga,Andrea M. Hujer,Robert A. Bonomo,James R. Knox +12 more
TL;DR: The design and synthesis of a series of seven tricyclic 6-methylidene penems as novel class A and C serine beta-lactamase inhibitors is described and the formation of the 1,4- thiazepine ring structures is proposed based on a 7-endo-trig cyclization.
Journal ArticleDOI
Structure-Activity Relationship of 6-Methylidene Penems Bearing 6,5 Bicyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Evidence for 1,4-Thiazepine Intermediates with C7 R Stereochemistry by Computational Methods
Aranapakam M. Venkatesan,Atul Agarwal,T. Abe,Hideki Ushirogochi,Itsuka Yamamura,Mihira Ado,Takasaki Tsuyoshi,Osvaldo Dos Santos,Yansong Gu,Fuk-Wah Sum,Li Zhong,Gerry Francisco,Yang-I. Lin,Petersen Peter J,Youjun Yang,T. Kumagai,William J. Weiss,David M. Shlaes,James R. Knox,Tarek S. Mansour +19 more
TL;DR: The design and synthesis of a series of 6-methylidene penems containing [6,5]-fused bicycles as novel class A, B, and C beta-lactamase inhibitors is described, and penems proposed to form a seven-membered 1,4 thiazepine ring in both class A and C Beta- lactamases are proposed.