Y
Youjun Yang
Researcher at University of Connecticut
Publications - 4
Citations - 209
Youjun Yang is an academic researcher from University of Connecticut. The author has contributed to research in topics: Thiazepine & Reaction intermediate. The author has an hindex of 3, co-authored 4 publications receiving 200 citations.
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Journal ArticleDOI
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.
Alexey Ruzin,Guy Singh,Anatoly Severin,Youjun Yang,Russell Dushin,Alan G. Sutherland,Albert Minnick,Michael Greenstein,Michael K. May,David M. Shlaes,Patricia A. Bradford +10 more
TL;DR: It was shown that mannopeptimycins interact with the membrane-bound cell wall precursor lipid II [C55-MurNAc-(peptide)-GlcNAc] and that this interaction is different from the binding of other lipid II-binding antibiotics such as vancomycin and mersacidin.
Journal ArticleDOI
Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates
Aranapakam M. Venkatesan,Yansong Gu,Osvaldo Dos Santos,T. Abe,Atul Agarwal,Youjun Yang,Petersen Peter J,William J. Weiss,Tarek S. Mansour,Michiyoshi Nukaga,Andrea M. Hujer,Robert A. Bonomo,James R. Knox +12 more
TL;DR: The design and synthesis of a series of seven tricyclic 6-methylidene penems as novel class A and C serine beta-lactamase inhibitors is described and the formation of the 1,4- thiazepine ring structures is proposed based on a 7-endo-trig cyclization.
Journal ArticleDOI
Structure-Activity Relationship of 6-Methylidene Penems Bearing 6,5 Bicyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Evidence for 1,4-Thiazepine Intermediates with C7 R Stereochemistry by Computational Methods
Aranapakam M. Venkatesan,Atul Agarwal,T. Abe,Hideki Ushirogochi,Itsuka Yamamura,Mihira Ado,Takasaki Tsuyoshi,Osvaldo Dos Santos,Yansong Gu,Fuk-Wah Sum,Li Zhong,Gerry Francisco,Yang-I. Lin,Petersen Peter J,Youjun Yang,T. Kumagai,William J. Weiss,David M. Shlaes,James R. Knox,Tarek S. Mansour +19 more
TL;DR: The design and synthesis of a series of 6-methylidene penems containing [6,5]-fused bicycles as novel class A, B, and C beta-lactamase inhibitors is described, and penems proposed to form a seven-membered 1,4 thiazepine ring in both class A and C Beta- lactamases are proposed.
Journal ArticleDOI
Synthesis and Structure—Activity Relationships of Novel THF 1β‐Methylcarbapenems. Part 2.
Y. Lin,Panayota Bitha,Subas M. Sakya,Strohmeyer Timothy W,Zhong Li,Ving J. Lee,S. A. Jun. Lang,Youjun Yang,Niraja Bhachech,William J. Weiss,Peter Petersen,N. V. Jacobus,Karen Bush,Testa Raymond T,F. P. Tally +14 more