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William L. Nicholson
Researcher at Centers for Disease Control and Prevention
Publications - 84
Citations - 5734
William L. Nicholson is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Spotted fever & Tick. The author has an hindex of 39, co-authored 81 publications receiving 5204 citations. Previous affiliations of William L. Nicholson include United States Department of Health and Human Services & Johns Hopkins University.
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Journal ArticleDOI
Nested PCR Assay for Detection of Granulocytic Ehrlichiae
Robert F. Massung,Kim Slater,Jessica H. Owens,William L. Nicholson,Thomas N. Mather,Victoria B. Solberg,James G. Olson +6 more
TL;DR: A sensitive and specific nested PCR assay was developed and used to examine acute-phase EDTA-blood and serum samples obtained from seven humans with clinical presentations compatible with human granulocytic ehrlichiosis, and the limit of detection was shown to be fewer than 2 copies of the 16S rRNA gene.
Journal Article
Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals.
Alice S. Chapman,Johan S. Bakken,Scott M. Folk,Christopher D. Paddock,Karen C. Bloch,Allan Krusell,Daniel J. Sexton,Steven C. Buckingham,Gary S. Marshall,Gregory Storch,Gregory A. Dasch,Jennifer H. McQuiston,David L. Swerdlow,Stephen J. Dumler,William L. Nicholson,David H. Walker,Marina E. Eremeeva,Christopher A. Ohl +17 more
TL;DR: This report will assist clinicians and other health-care and public health professionals to develop a differential diagnosis that includes and ranks TBRD, understand that the recommendations for doxycycline are the treatment of choice for both adults and children, and understand that early empiric antibiotic therapy can prevent severe morbidity and death.
Journal ArticleDOI
Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States.
Holly M. Biggs,Casey Barton Behravesh,Kristy K. Bradley,F. Scott Dahlgren,Naomi A. Drexler,J. Stephen Dumler,Scott M. Folk,Cecilia Y. Kato,R. Ryan Lash,Michael Levin,Robert F. Massung,Robert B. Nadelman,William L. Nicholson,Christopher D. Paddock,Bobbi S. Pritt,Marc S. Traeger +15 more
TL;DR: The CDC Rickettsial Zoonoses Branch developed this report to assist health care providers and public health professionals to recognize key epidemiologic features and clinical manifestations of tickborne rickettsial diseases, and understand that early empiric antibacterial therapy can prevent severe disease and death.
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Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study.
John A. Crump,Anne B. Morrissey,William L. Nicholson,Robert F. Massung,Robyn A. Stoddard,Renee L. Galloway,Eng Eong Ooi,Venance P. Maro,Wilbrod Saganda,Grace D. Kinabo,Charles Muiruri,John Bartlett +11 more
TL;DR: An integrated approach to the syndrome of fever in resource-limited areas is needed to improve patient outcomes and to rationally target disease control efforts.
Journal ArticleDOI
PCR amplification and comparison of nucleotide sequences from the groESL heat shock operon of Ehrlichia species.
TL;DR: Degenerate PCR primers derived from conserved regions of the eubacterial groESL heat shock operon were used to amplifyGroESL sequences of Ehrlichia equi, EHRlichia phagocytophila, and the agent of human granulocytic ehrlichiosis, and a phylogenetic tree derived from deduced GroEL amino acid sequences was similar to trees based on 16S rRNA gene sequences.