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William P. Arend
Researcher at University of Colorado Denver
Publications - 130
Citations - 26901
William P. Arend is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Receptor & Interleukin 1 receptor antagonist. The author has an hindex of 61, co-authored 130 publications receiving 25520 citations. Previous affiliations of William P. Arend include Anschutz Medical Campus & University of Texas Health Science Center at Houston.
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Journal Article
Absence of induction of IL-1 production in human monocytes by complement fragments.
TL;DR: Results indicate that various solid phase or soluble C fragments, including C3b, iC3b), C3d, C3a, C5a, Ba or Bb do not induce IL-1 production in human monocytes in the absence of contaminating endotoxin.
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Intracellular IL-1 Receptor Antagonist Type 1 Inhibits IL-1-Induced Cytokine Production in Keratinocytes through Binding to the Third Component of the COP9 Signalosome
Nirmal K. Banda,Carla J. Guthridge,Devon Sheppard,Kelly S. Cairns,Michele Muggli,Dawadschargal Bech-Otschir,Wolfgang Dubiel,William P. Arend +7 more
TL;DR: icIL-1Ra1 exhibits unique anti-inflammatory properties inside cells through binding to CSN3 with subsequent inhibition of the p38 MAPK signal transduction pathway.
Journal Article
Intracellular IL-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions.
J K Jenkins,R F Drong,M E Shuck,Michael J. Bienkowski,J L Slightom,William P. Arend,M F Smith +6 more
TL;DR: The results indicate that the ability of this proximal promoter region to control expression is strongly influenced, both positively and negatively, by other upstream cis-acting elements in a cell type-specific manner.
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Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.
Nirmal K. Banda,Brandt Levitt,Allyson Wood,Kazue Takahashi,Gregory L. Stahl,V M Holers,William P. Arend +6 more
TL;DR: It is concluded that neither the CP nor LP alone is capable of mediating CAIA in vivo and that mouse sera exhibits a high level of IgG‐induced C5a generation in vitro through either the CP or AP.
Journal ArticleDOI
Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase.
TL;DR: The absence of EC-SOD leads to more severe CIA, which may be accompanied by enhanced production of the proinflammatory cytokines IFNgamma, TNFalpha, and IL-1beta, and decreasedProduction of the antiinflammatory cytokine IL- 1Ra in the joints.