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William P. Sheffield
Researcher at Canadian Blood Services
Publications - 132
Citations - 2271
William P. Sheffield is an academic researcher from Canadian Blood Services. The author has contributed to research in topics: Thrombin & Serpin. The author has an hindex of 24, co-authored 122 publications receiving 2067 citations. Previous affiliations of William P. Sheffield include McMaster University Medical Centre & RAND Corporation.
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Journal ArticleDOI
Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence.
TL;DR: The results indicate that Hsp 70 can retard precursor polypeptide folding and prevent precursor aggregation; however, by itself, Hsp70 cannot confer import competence to pO-DHFR.
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Potent Antithrombin Activity and Delayed Clearance From the Circulation Characterize Recombinant Hirudin Genetically Fused to Albumin
TL;DR: The results provide a rationale for future testing of the biological effects of HLA, and support the initial hypothesis that gene fusion of hirudin to albumin would result in the expression of a slowly cleared hirUDin molecule, as well as retention of high-affinity inhibition of thrombin by the fusion protein.
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Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate
Melissa D. Lambourne,Louise J. Eltringham-Smith,Sharon Gataiance,Donald M. Arnold,Donald M. Arnold,Mark Crowther,William P. Sheffield +6 more
TL;DR: Both established oral anticoagulants such as warfarin and newer agents such as dabigatran etexilate (DE) effectively prevent thromboembolic disease, but may provoke bleeding.
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Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin.
Syed M. Qadri,Syed M. Qadri,David A. Donkor,David A. Donkor,Varsha Bhakta,Louise J. Eltringham-Smith,Dhruva J. Dwivedi,Jane C. Moore,Laura Pepler,Nikola Ivetic,Ishac Nazi,Alison Fox-Robichaud,Patricia C. Liaw,William P. Sheffield,William P. Sheffield +14 more
TL;DR: The present study discloses the eryptosis‐inducing effect of the virulence factor pyocyanin, thereby shedding light on a potentially important mechanism in the systemic complications of P. aeruginosa infection.
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Cytokeratin 18 Is Expressed on the Hepatocyte Plasma Membrane Surface and Interacts with Thrombin-Antithrombin Complexes
Michael J. Wells,Mark W.C. Hatton,Bryan R. Hewlett,Thomas J. Podor,William P. Sheffield,Morris A. Blajchman +5 more
TL;DR: Evidence is provided that CK18 is found on the extracellular surface of hepatocytes and could play a role in TAT removal, in conjunction with recent reports of CK8 and CK1, which indicate a novel role for these proteins as putative cellular receptors or cofactors to cellular receptors.