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William R. Wagner
Researcher at University of Pittsburgh
Publications - 344
Citations - 17976
William R. Wagner is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Platelet activation & Tissue engineering. The author has an hindex of 69, co-authored 330 publications receiving 16481 citations. Previous affiliations of William R. Wagner include Boston Children's Hospital & Carnegie Mellon University.
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Journal ArticleDOI
Microbubbles Targeted to Intercellular Adhesion Molecule-1 Bind to Activated Coronary Artery Endothelial Cells
Flordeliza S. Villanueva,Ron J. Jankowski,Sasha Klibanov,Maris L. Pina,Sean Alber,Simon C. Watkins,Gary H. Brandenburger,William R. Wagner +7 more
TL;DR: A gas-filled microbubble with anti-ICAM-1 antibody on its shell specifically binds to activated ECs overexpressing ICam-1.
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Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications
TL;DR: Smooth muscle cells were filtration seeded in the scaffolds and it was shown that both scaffolds supported cell adhesion and growth, with smooth muscle cells growing more extensively in the PEUU scaffold.
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Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropy.
TL;DR: This study developed ES-PEUU scaffolds under variable speed conditions and modeled the effects of fiber orientation on the macro-mechanical properties of the scaffold, which will help to provide the basis for rationally designed mechanically anisotropic soft tissue engineered implants.
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Microintegrating smooth muscle cells into a biodegradable, elastomeric fiber matrix.
TL;DR: Electrospraying vascular smooth muscle cells (SMCs) concurrently with electrospinning a biodegradable, elastomeric poly(ester urethane)urea (PEUU) matrix embodies a novel tissue engineering approach that could be applied to fabricate high cell density elastic tissue mimetics, blood vessels or other cardiovascular tissues.
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Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease
Fouzia Laghrissi-Thode,William R. Wagner,Bruce G. Pollock,Peter C. Johnson,Mitchell S. Finkel +4 more
TL;DR: This study investigated the hypothesis that patients suffering from ischemic heart disease and depression concurrently may have abnormal platelet activation resulting in an increased risk of thrombosis.