Kazuro Fujimoto

TL;DR: Smooth muscle cells were filtration seeded in the scaffolds and it was shown that both scaffolds supported cell adhesion and growth, with smooth muscle cells growing more extensively in the PEUU scaffold.

TL;DR: Electrospraying vascular smooth muscle cells (SMCs) concurrently with electrospinning a biodegradable, elastomeric poly(ester urethane)urea (PEUU) matrix embodies a novel tissue engineering approach that could be applied to fabricate high cell density elastic tissue mimetics, blood vessels or other cardiovascular tissues.

TL;DR: The designed poly(NIPAAm-co-AAc- co-HEMAPTMC) hydrogel of this report may offer an attractive biomaterial-centered treatment option for ischemic cardiomyopathy.

TL;DR: This method to rapidly and efficiently integrate cells into a strong, compliant biodegradable tubular matrix represents a significant achievement as a tissue engineering approach for blood vessel replacement.

TL;DR: The literature to date generally demonstrates acute functional benefits associated with biomaterial injection therapy across a broad variety of animal models and material compositions, and further functional improvements have been reported when cellular or pharmaceutical agents have been incorporated into the delivery system.