W
Winnie H. Sim
Researcher at Royal Children's Hospital
Publications - 6
Citations - 337
Winnie H. Sim is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: Inflammatory bowel disease & Virus. The author has an hindex of 6, co-authored 6 publications receiving 281 citations.
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Journal ArticleDOI
Association between specific mucosa-associated microbiota in Crohn's disease at the time of resection and subsequent disease recurrence: a pilot study
Peter De Cruz,Peter De Cruz,Seungha Kang,Josef Wagner,Michael Buckley,Winnie H. Sim,Lani Prideaux,Lani Prideaux,Trevor Lockett,Christopher S. McSweeney,Mark Morrison,Mark Morrison,Carl D. Kirkwood,Michael A. Kamm,Michael A. Kamm,Michael A. Kamm +15 more
TL;DR: This work characterized the mucosa‐associated microbiota at the time of surgical resection and 6 months later to identify bacterial profiles associated with recurrence and remission in Crohn's disease.
Journal ArticleDOI
Bacteriophages in gut samples from pediatric Crohn's disease patients: metagenomic analysis using 454 pyrosequencing.
Josef Wagner,Jovana Maksimovic,Gabriella Farries,Winnie H. Sim,Ruth F. Bishop,Donald J. S. Cameron,Anthony G. Catto-Smith,Anthony G. Catto-Smith,Carl D. Kirkwood,Carl D. Kirkwood +9 more
TL;DR: The large abundance of phages in CD ileum tissue and CD gut wash sample suggests a role of phage in CD development, and identifies differences in phage composition between CD patients and control individuals.
Journal ArticleDOI
Interaction of Crohn's Disease Susceptibility Genes in an Australian Paediatric Cohort
Josef Wagner,Winnie H. Sim,Justine A. Ellis,Eng K. Ong,Anthony G. Catto-Smith,Anthony G. Catto-Smith,Donald J. S. Cameron,Ruth F. Bishop,Carl D. Kirkwood +8 more
TL;DR: It is demonstrated that CD genetic susceptibility in paediatric patients presents as a complex interaction between numerous genes, both at the individual level or in gene-gene interactive roles.
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Current knowledge and systematic review of viruses associated with Crohn's disease
Josef Wagner,Josef Wagner,Winnie H. Sim,Katherine J Lee,Katherine J Lee,Carl D. Kirkwood,Carl D. Kirkwood,Carl D. Kirkwood +7 more
TL;DR: The current literature surrounding the association between viruses and CD is summarized and a systematic review of all studies investigating this association quantitatively is conducted.
Journal ArticleDOI
Expression profile of genes involved in pathogenesis of pediatric Crohn's disease.
Winnie H. Sim,Josef Wagner,Donald J. S. Cameron,Anthony G. Catto-Smith,Ruth F. Bishop,Carl D. Kirkwood +5 more
TL;DR: expression profiling of genes specific to pediatric Crohn's Disease patients was performed to elucidate the molecular mechanisms underlying disease cause and pathogenesis at disease onset.