J
Justine A. Ellis
Researcher at University of Melbourne
Publications - 109
Citations - 3931
Justine A. Ellis is an academic researcher from University of Melbourne. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 32, co-authored 107 publications receiving 3428 citations. Previous affiliations of Justine A. Ellis include Royal Children's Hospital & Deakin University.
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Journal ArticleDOI
Polymorphism of the androgen receptor gene is associated with male pattern baldness.
TL;DR: The ubiquity of the androgen receptor gene StuI restriction site, and higher incidence of shorter triplet repeat haplotypes in bald men suggests that these markers are very close to a functional variant that is a necessary component of the polygenic determination of male pattern baldness.
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Androgenetic alopecia: pathogenesis and potential for therapy.
TL;DR: Discovery of the involvement of the AR gene, and the identification of other genes contributing to the condition, might lead to the development of new and more effective therapies that target the condition at a more fundamental level.
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Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Yun Li,Jin Li,Sihai Dave Zhao,Sihai Dave Zhao,Jonathan P. Bradfield,Frank D. Mentch,S. Melkorka Maggadottir,Cuiping Hou,Debra J. Abrams,Diana Chang,Feng Gao,Yiran Guo,Zhi Wei,John Connolly,Christopher J. Cardinale,Marina Bakay,Joseph T. Glessner,Dong Li,Charlly Kao,Kelly A. Thomas,Haijun Qiu,Rosetta M. Chiavacci,Cecilia E. Kim,Fengxiang Wang,James Snyder,Marylyn D Richie,Berit Flatø,Øystein Førre,Lee A. Denson,Susan D. Thompson,Mara L. Becker,Stephen L. Guthery,Anna Latiano,Elena E. Perez,Elena S. Resnick,Richard K Russell,David C. Wilson,Mark S. Silverberg,Vito Annese,Benedicte A. Lie,Marilynn Punaro,Marla Dubinsky,Dimitri S. Monos,Caterina Strisciuglio,Annamaria Staiano,Erasmo Miele,Subra Kugathasan,Justine A. Ellis,Jane E Munro,Kathleen E. Sullivan,Carol Wise,Helen Chapel,Charlotte Cunningham-Rundles,Struan F.A. Grant,Jordan S. Orange,Patrick M. A. Sleiman,Edward M. Behrens,Anne M. Griffiths,Jack Satsangi,Terri H. Finkel,Alon Keinan,Eline T. Luning Prak,Constantin Polychronakos,Robert N. Baldassano,Hongzhe Li,Brendan J. Keating,Hakon Hakonarson +66 more
TL;DR: Network and protein-interaction analyses demonstrated converging roles for the signaling pathways of type 1, 2 and 17 helper T cells (TH1, TH2 and TH17), JAK-STAT, interferon and interleukin in multiple autoimmune diseases.
Journal ArticleDOI
Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase
Erika Salvi,Zoltán Kutalik,Nicola Glorioso,Paola Benaglio,Francesca Frau,Tatiana Kuznetsova,Hisatomi Arima,Clive J. Hoggart,Jean Tichet,Y Nikitin,Costanza Conti,Jitka Seidlerová,Valérie Tikhonoff,Katarzyna Stolarz-Skrzypek,Toby Johnson,Nabila Devos,Laura Zagato,Simonetta Guarrera,Roberta Zaninello,Andrea Calabria,Benedetta Stancanelli,Chiara Troffa,Lutgarde Thijs,Federica Rizzi,Galina Simonova,Sara Lupoli,Giuseppe Argiolas,Daniele Braga,Maria C. D'Alessio,Maria Francesca Ortu,Fulvio Ricceri,Maurizio Mercurio,Patrick Descombes,Maurizio Marconi,John Chalmers,Stephen B. Harrap,Jan Filipovsky,Murielle Bochud,Licia Iacoviello,Justine A. Ellis,Alice Stanton,Maris Laan,Sandosh Padmanabhan,Anna F. Dominiczak,Nilesh J. Samani,Olle Melander,Xavier Jeunemaitre,Paolo Manunta,Amnon Shabo,Paolo Vineis,Francesco P. Cappuccio,Mark J. Caulfield,Giuseppe Matullo,Carlo Rivolta,Patricia B. Munroe,Cristina Barlassina,Jan A. Staessen,Jacques S. Beckmann,Daniele Cusi +58 more
TL;DR: Biological evidence links endothelial NO synthase with hypertension, because it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation, and the hypothesis that there may be a causal genetic variation at this locus is supported.
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Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes
TL;DR: The findings suggest that the genes encoding the two 5α-reductase isoenzymes are not associated with male pattern baldness.