Wolfgang Becker

TL;DR: A variety of basic compounds is capable of inhibiting the tubular reabsorption of peptides and proteins, thus lowering the kidney uptake of antibody fragments significantly, and their role as imaging and therapeutic agents may be expanded.

TL;DR: Antigranulocyte Fab'-fragment may have its advantage in an earlier localization of infectious lesions (1 hour) owing to its smaller molecular size and its lower affinity for its epitope, which may be promising in the detection of spinal infections and in infections in regions with the presence of normal bone marrow.

TL;DR: CCK/gastrin analogs may be a useful new class of receptor-binding peptides for diagnosis and therapy of CCK-B receptor-expressing tumors, such as MTC or small cell lung cancer.

TL;DR: Assessment of the toxicity and antitumor efficacy of RIT with the alpha emitter 213Bi/213Po, as compared to the beta emitter 90Y, linked to a monovalent Fab' fragment in a human colonic cancer xenograft model in nude mice shows that R IT with alpha emitters may be therapeutically more effective than conventional beta emitters.

TL;DR: Investigation of the use of 99mTc-murine anti-granulocyte monoclonal Fab' fragment in patients with suspected osteomyelitis of soft-tissue infections found it offers rapid localization of foci, rapid and simple use, a negligible HAMA response rate, no effect on granulocyte function and an accuracy comparable to WBC scanning.