E
Ellen Witte
Researcher at Charité
Publications - 27
Citations - 6248
Ellen Witte is an academic researcher from Charité. The author has contributed to research in topics: Cytokine & Psoriasis. The author has an hindex of 22, co-authored 27 publications receiving 5746 citations.
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Journal ArticleDOI
IL-22 increases the innate immunity of tissues.
Kerstin Wolk,Stefanie Kunz,Ellen Witte,Markus Friedrich,Khusru Asadullah,Robert Sabat,Robert Sabat +6 more
TL;DR: IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues.
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IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes : a potential role in psoriasis
Kerstin Wolk,Ellen Witte,Elizabeth Wallace,Wolf-Dietrich Döcke,Stefanie Kunz,Khusru Asadullah,Hans-Dieter Volk,Wolfram Sterry,Robert Sabat +8 more
TL;DR: It is demonstrated that IL‐22, in contrast to its relative IFN‐γ, regulates the expression of only a few genes in keratinocytes, which may be important in the innate immunity and reorganization of epithelia.
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Biology of interleukin-10
Robert Sabat,Gerald Grütz,Katarzyna Warszawska,Stefan Kirsch,Ellen Witte,Kerstin Wolk,Jens Geginat +6 more
TL;DR: The special physiological relevance of this cytokine lies in the prevention and limitation of over-whelming specific and unspecific immune reactions and, in consequence, of tissue damage.
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IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not
Kerstin Wolk,Harald S. Haugen,Wenfeng Xu,Ellen Witte,Kim Waggie,Monica Anderson,Elmar vom Baur,Katrin Witte,Katarzyna Warszawska,Sandra Philipp,Caroline Johnson-Leger,Hans-Dieter Volk,Wolfram Sterry,Robert Sabat +13 more
TL;DR: It is suggested that different cytokines are players in the psoriasis pathogenesis although only the IL-10 family members IL-22 and IL-20 directly cause the characteristic epidermal alterations.
Journal ArticleDOI
Biology of interleukin-22
TL;DR: This chapter illuminates in detail the properties of IL-22 with respect to its gene, protein structure, cellular sources, receptors, target cells, biological effects, and, finally, its role in chronic inflammatory diseases, tumors, and infection.