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Woon-Khiong Chan
Researcher at National University of Singapore
Publications - 51
Citations - 4354
Woon-Khiong Chan is an academic researcher from National University of Singapore. The author has contributed to research in topics: Embryonic stem cell & Zebrafish. The author has an hindex of 25, co-authored 50 publications receiving 4140 citations.
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Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells.
TL;DR: It is shown that human fetal and adult fibroblast feeders support prolonged undifferentiated HES cell growth of existing cell lines and are superior to cell-free matrices supplemented with human or MEF feeder–conditioned medium.
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The Transcriptome Profile of Human Embryonic Stem Cells as Defined by SAGE
TL;DR: The overlapping similarities and differences in gene expression profiles of human and mouse ES cells provide a foundation for a detailed and concerted dissection of the molecular and cellular mechanisms governing their pluripotency, directed differentiation into specific cell types, and extended ability for self‐renewal.
Journal ArticleDOI
Extraordinary salmon growth
Robert H. Devlin,Timothy Y. Yesaki,Carlo A. Biagi,Edward M. Donaldson,Penny Swanson,Woon-Khiong Chan +5 more
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Comparative Evaluation of Various Human Feeders for Prolonged Undifferentiated Growth of Human Embryonic Stem Cells
TL;DR: It is reported that two adult skin fibroblast cell lines established in‐house from abdominal skin biopsies supported prolonged undifferentiated hES cell growth for over 30 weekly passages in culture.
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Human Wharton’s Jelly Stem Cells Have Unique Transcriptome Profiles Compared to Human Embryonic Stem Cells and Other Mesenchymal Stem Cells
Chui-Yee Fong,Li-Ling Chak,Arijit Biswas,Jee-Hian Tan,Kalamegam Gauthaman,Woon-Khiong Chan,Ariff Bongso +6 more
TL;DR: The ability to modulate immune responses makes hWJSCs an important compatible stem cell source for transplantation therapy in allogeneic settings without immunorejection and provides a foundation for future functional studies where the exact mechanisms of these unique properties of hW JSCs can be confirmed.