Wupeng Liao

TL;DR: An update on vitamin E therapeutic potentials, protective effects and modes of action beyond cancer, with comparison of tocopherols against tocotrienols.

TL;DR: The renin–angiotensin system (RAS) has also been implicated in the regulation of inflammation, proliferation and fibrosis in pulmonary diseases such as asthma, acute lung injury, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

TL;DR: Taken together, andrographolide and its analogs have great potential to be the next new class of anti‐inflammatory agents, and more androg grapholide molecules are likely moving towards clinical study stage in the near future.

TL;DR: In conclusion, inhibition of glycogen synthase kinase-3beta may provide a novel means for the treatment of allergic airway inflammation by significantly inhibited ovalbumin-induced increases in total cell counts, eosinophil counts, and IL-5, IL-13, and eotaxin levels recovered in bronchoalveolar lavage fluid in a dose-dependent manner.

TL;DR: This review will compile the current findings of oligonucleotide therapeutic targets, verified in various respiratory disease models and in clinical trials, and evaluate different chemical modification approaches to improve the stability and potency of olig onucleotides for the treatment of respiratory diseases.