W
Wyatt Bunner
Researcher at East Carolina University
Publications - 15
Citations - 174
Wyatt Bunner is an academic researcher from East Carolina University. The author has contributed to research in topics: Neurodegeneration & Neuron. The author has an hindex of 6, co-authored 11 publications receiving 111 citations.
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Journal ArticleDOI
The effects of exercise on hypothalamic neurodegeneration of Alzheimer's disease mouse model
Khoa Do,Brenton Thomas Laing,Taylor Landry,Wyatt Bunner,Naderi Mersaud,Tomoko Matsubara,Peixin Li,Yuan Yuan,Qun Lu,Hu Huang +9 more
TL;DR: The results indicated that early onset of metabolic abnormalities may contribute to the pathology of AD, which is associated with increased inflammation as well as decreased neuronal population and key neuropeptides in the hypothalamus, and a hypothalamic-mediated mechanism where exercise prevents the progression of dementia and of Alzheimer's disease.
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Administration of alpha Klotho reduces liver and adipose lipid accumulation in obese mice.
TL;DR: There is a need for further research into the specific mechanisms explaining improved body composition, elevated energy expenditure, and reduced lipid content in both liver and adipose tissue in α-Klotho-treated mice.
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ARCAgRP/NPY Neuron Activity Is Required for Acute Exercise-Induced Food Intake in Un-Trained Mice.
TL;DR: Investigation of the effects of acute, moderate-intensity exercise on food intake and neuronal activity in the arcuate nucleus (ARC) of the hypothalamus reveals that ARCAgRP/NPY activation is required for acute exercise induced food intake in mice, thus providing insight into the critical role of ARCAGRP/ NPY neurons in maintaining energy homeostasis in cases of exercise-mediated energy deficit.
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Central α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice.
Taylor Landry,Brenton Thomas Laing,Peixin Li,Wyatt Bunner,Zhijian Rao,Amber Prete,Julia Sylvestri,Hu Huang +7 more
TL;DR: A prominent role of hypothalamic α-klotho/FGFR1/PI3K signaling in the modulation of NPY/AgRP neuron activity and maintenance of energy homeostasis is indicated, thus providing new insight into the pathophysiology of metabolic disease.
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Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice.
Taylor Landry,Peixin Li,Daniel Shookster,Zhiying Jiang,Hongli Li,Brenton Thomas Laing,Wyatt Bunner,Theodore Langton,Qingchun Tong,Hu Huang +9 more
TL;DR: Human CSF data provide the first evidence that impaired central α-klotho function may be involved in the pathophysiology of obesity, and results in mouse models identify ARC POMC neurons and astrocytes as novel molecular effectors of centralα- Klotho.