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Qingchun Tong
Researcher at University of Texas Health Science Center at Houston
Publications - 110
Citations - 4485
Qingchun Tong is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 30, co-authored 89 publications receiving 3515 citations. Previous affiliations of Qingchun Tong include SUNY Downstate Medical Center & Chinese Academy of Sciences.
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Journal ArticleDOI
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
TL;DR: These mice with an AgRP neuron–specific deletion of vesicular GABA transporter are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin, indicating that GABA release from AgRP neurons is important in regulating energy balance.
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Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
Qingchun Tong,Chianping Ye,Rory J. McCrimmon,Harveen Dhillon,Brian Choi,Melissa D. Kramer,Jia Yu,Zongfang Yang,Lauryn M. Christiansen,Charlotte E. Lee,Cheol Soo Choi,Jeffrey M. Zigman,Gerald I. Shulman,Robert S. Sherwin,Joel K. Elmquist,Bradford B. Lowell +15 more
TL;DR: Glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia in mice lacking VGLUT2 selectively in SF1 neurons.
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VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch
Yang Liu,Omar Abdel Samad,Ling Zhang,Bo Duan,Qingchun Tong,Claudia Lopes,Ru-Rong Ji,Bradford B. Lowell,Qiufu Ma +8 more
TL;DR: These studies suggest that synaptic glutamate release from a group of peripheral nociceptors is required to sense pain and suppress itch, and create a mouse model of chronic neurogenic itch.
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GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure
Dong Kong,Qingchun Tong,Qingchun Tong,Chianping Ye,Shuichi Koda,Patrick M. Fuller,Michael J. Krashes,Linh Vong,Russell S. Ray,David P. Olson,Bradford B. Lowell +10 more
TL;DR: Acute, selective activation of arcuate GABAergic RIP-Cre neurons in the arcuate selectively drive energy expenditure, contribute to leptin's stimulatory effect on thermogenesis, and protect against diet-induced obesity.
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Glucose Stimulation of Hypothalamic MCH Neurons Involves KATP Channels, is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis
Dong Kong,Linh Vong,Laura E. Parton,Chianping Ye,Qingchun Tong,Xiaoxia Hu,Brian Choi,Jens C. Brüning,Bradford B. Lowell +8 more
TL;DR: It is demonstrated that glucose excitation of MCH-expressing neurons in the lateral hypothalamus is mediated by K(ATP) channels and is negatively regulated by UCP2 (a mitochondrial protein that reduces ATP production), and that glucose sensing by MCH neurons plays an important role in regulating glucose homeostasis.