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Xaveer Van Ostade
Researcher at University of Adelaide
Publications - 2
Citations - 331
Xaveer Van Ostade is an academic researcher from University of Adelaide. The author has contributed to research in topics: Proinflammatory cytokine & Tumor necrosis factor alpha. The author has an hindex of 2, co-authored 2 publications receiving 327 citations. Previous affiliations of Xaveer Van Ostade include University of Edinburgh & Ghent University.
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Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-α: Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro
Joanna Murray,Joanna Murray,Joanna Murray,Jeffrey A.J. Barbara,Jeffrey A.J. Barbara,Jeffrey A.J. Barbara,Sarah A. Dunkley,Sarah A. Dunkley,Sarah A. Dunkley,Angel F. Lopez,Angel F. Lopez,Angel F. Lopez,Xaveer Van Ostade,Xaveer Van Ostade,Xaveer Van Ostade,Alison M. Condliffe,Alison M. Condliffe,Alison M. Condliffe,Ian Dransfield,Christopher Haslett,Edwin R. Chilvers,Edwin R. Chilvers,Edwin R. Chilvers +22 more
TL;DR: TNF-alpha has the unique ability to induce apoptosis in human neutrophils via a mechanism where TNFR75 facilitates the dominant TNFR55 death effect, and may be an important mechanism controlling neutrophil longevity and clearance in vivo.
Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-a: Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro
Joanna Murray,Sarah A. Dunkley,Angel F. Lopez,Xaveer Van Ostade,Alison M. Condliffe,Ian Dransfield,C Haslett,Edwin R. Chilvers +7 more
TL;DR: In this paper, the authors examined whether neutrophil priming TNFR55-selective TNF-a mutants (E146K, R32W-S86T, and D143F) induced neutrophIL apoptosis but with a potency 14-fold lower agents.