A
Alison M. Condliffe
Researcher at University of Sheffield
Publications - 108
Citations - 7718
Alison M. Condliffe is an academic researcher from University of Sheffield. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 36, co-authored 96 publications receiving 6501 citations. Previous affiliations of Alison M. Condliffe include University of Cambridge & National Health Service.
Papers
More filters
Journal ArticleDOI
Neutrophil kinetics in health and disease
Charlotte Summers,Sara M. Rankin,Alison M. Condliffe,Nanak R. Singh,A. Michael Peters,Edwin R. Chilvers +5 more
TL;DR: Current understanding of how neutrophils are released from the bone marrow is outlined, in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis and the relative size and role of freely circulating and marginated pools within the vascular compartment are outlined.
Journal ArticleDOI
Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity
Sarah R. Walmsley,Cristin G. Print,Neda Farahi,Carole Peyssonnaux,Randall S. Johnson,Thorsten Cramer,Anastasia Sobolewski,Alison M. Condliffe,Andrew S. Cowburn,Nicola Johnson,Edwin R. Chilvers +10 more
TL;DR: It is shown that neutrophils possess the hypoxia-inducible factor (HIF)-1α and factor inhibiting HIF (FIH) hydroxylase oxygen-sensing pathway and that HIF-1α is directly involved in regulating neutrophil survival in hypoxIA.
Journal ArticleDOI
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
Ivan Angulo,Oscar Vadas,Fabien Garçon,Edward Banham-Hall,Vincent Plagnol,Timothy Ronan Leahy,Timothy Ronan Leahy,Helen Baxendale,Tanya I. Coulter,Tanya I. Coulter,James Curtis,Changxin Wu,Katherine G. Blake-Palmer,Olga Perisic,Deborah J. Smyth,Mailis Maes,Christine A Fiddler,Jatinder K. Juss,Deirdre Cilliers,Gašper Markelj,Anita Chandra,George Farmer,Anna Kielkowska,Jonathan Clark,Sven Kracker,Sven Kracker,Marianne Debré,Capucine Picard,Capucine Picard,Isabelle Pellier,Nada Jabado,James Morris,Gabriela Barcenas-Morales,Alain Fischer,Alain Fischer,Len R. Stephens,Phillip T. Hawkins,Jeffrey C. Barrett,Mario Abinun,Menna R. Clatworthy,Anne Durandy,Rainer Doffinger,Edwin R. Chilvers,Andrew J. Cant,Dinakantha S. Kumararatne,Klaus Okkenhaug,Roger L. Williams,Alison M. Condliffe,Sergey Nejentsev +48 more
TL;DR: Activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110δ protein, the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ), encoded by the PIK3CD gene is described.
Journal ArticleDOI
Neutrophil Priming: Pathophysiological Consequences and Underlying Mechanisms
TL;DR: The ability of neutrophils to undergo a complete cycle of priming-de-priming (and re- priming) reveals a previously unrecognized flexibility in the control of neutrophic behaviour at an inflamed site.
Journal ArticleDOI
The neutrophil in chronic obstructive pulmonary disease.
TL;DR: It has recently become apparent that hypoxia can influence neutrophil function, with impaired killing of pathogenic bacteria, enhanced release of proteases, and delayed apoptosis.