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Virginie Caux-Moncoutier

Researcher at Curie Institute

Publications -  32
Citations -  3133

Virginie Caux-Moncoutier is an academic researcher from Curie Institute. The author has contributed to research in topics: Breast cancer & Gene. The author has an hindex of 23, co-authored 31 publications receiving 2656 citations. Previous affiliations of Virginie Caux-Moncoutier include PSL Research University & Paris Descartes University.

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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig E. Bojesen, +455 more
- 01 Apr 2013 - 
TL;DR: Using the Illumina custom genotyping array iCOGs, SNPs at the TERT locus in breast, ovarian and BRCA1 mutation carrier cancer cases and controls and leukocyte telomere measurements are analyzed to find associations cluster into three independent peaks.
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Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

Tatiana Popova, +14 more
- 01 Nov 2012 - 
TL;DR: The genomic signature defined predicted BRCA1/2 inactivation in BLCs with 100% sensitivity and 90% specificity (97% accuracy) may ease the challenge of selecting patients for genetic testing or recruitment to clinical trials of novel emerging therapies that target DNA repair deficiencies in cancer.
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

Roger L. Milne, +512 more
- 23 Oct 2017 - 
TL;DR: A genome-wide association study (GWAS) of predominantly estrogen receptor (ER)-positive disease and BRCA1 mutation carrier GWAS observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies, which explain approximately 16% of the familial risk of this breast cancer subtype.
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Germline BAP1 mutations predispose to renal cell carcinomas.

Tatiana Popova, +35 more
- 06 Jun 2013 - 
TL;DR: Using whole-exome sequencing and tumor profiling in a family prone to cases of RCC, a germline BAP1 mutation c.277A>G (p.Thr93Ala) is identified as the probable genetic basis of R CC predisposition and BAP 1 was found to be inactivated in RCC-affected individuals from this family.
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Guidelines for splicing analysis in molecular diagnosis derived from a set of 327 combined in silico/in vitro studies on BRCA1 and BRCA2 variants.

Claude Houdayer, +29 more
- 01 Aug 2012 - 
TL;DR: This study embarked upon the largest BRCA1 and BRCa2 splice study to date by testing 272 VUSs within the BRC a splice network of Unicancer, and defined guidelines for transcript analysis along with a tentative classification of splice variants.