X
Xi Wang
Researcher at Chinese Academy of Sciences
Publications - 44
Citations - 20127
Xi Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 26 publications receiving 14582 citations.
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Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
J.D. Liu,Ruiyuan Cao,Mingyue Xu,Xi Wang,Huanyu Zhang,Hengrui Hu,Yufeng Li,Zhihong Hu,Wu Zhong,Manli Wang +9 more
TL;DR: Evaluated the antiviral effect of HCQ against SARS-CoV-2 infection in comparison to CQ in vitro and concluded that CQ appears to be the drug of choice for large-scale use due to its availability, proven safety record, and a relatively low cost.
Posted ContentDOI
Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: The identification and characterization of a novel coronavirus (nCoV-2019) which caused an epidemic of acute respiratory syndrome in humans, in Wuhan, China, and it is confirmed that this novel CoV uses the same cell entry receptor, ACE2, as SARS-CoV.
Journal ArticleDOI
Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone.
Lei Wang,Xi Wang,Chih-chen Wang +2 more
TL;DR: The structural features of PDI are highlighted, including the high interdomain flexibility, the multiple binding sites, the two synergic active sites, and the redox-dependent conformational changes.
Journal ArticleDOI
Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4
TL;DR: Either deletion of the YF motif or dissociation into dimers decreased the susceptibility of Prx4 to overoxidation by increasing the flexibility of Cys87, and the structural explanation for the restricting role of theYF motif on the active site dynamics is provided.