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Xia Wu
Researcher at Capital Medical University
Publications - 14
Citations - 434
Xia Wu is an academic researcher from Capital Medical University. The author has contributed to research in topics: Piperlonguminine & Penthorum chinense. The author has an hindex of 9, co-authored 12 publications receiving 315 citations.
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Journal ArticleDOI
Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models.
Jia Liu,Weijin Liu,Yongquan Lu,Hao Tian,Chunli Duan,Lingling Lu,Ge Gao,Xia Wu,Xiaomin Wang,Hui Yang +9 more
TL;DR: It is demonstrated that PLG exerts therapeutic effects in a rotenone-induced PD models by restoring the balance between apoptosis and autophagy.
Journal ArticleDOI
Identification and simultaneous quantification of five alkaloids in Piper longum L. by HPLC–ESI-MSn and UFLC–ESI-MS/MS and their application to Piper nigrum L.
TL;DR: A simple, effective and suitable UFLC-ESI-MS/MS method was firstly developed to simultaneously determine five characteristic constituents of Piper longum L. longum, which had lower piperine content but was enriched in the other four alkaloids.
Journal ArticleDOI
Simultaneous UFLC–ESI–MS/MS determination of piperine and piperlonguminine in rat plasma after oral administration of alkaloids from Piper longum L.: Application to pharmacokinetic studies in rats
TL;DR: The UFLC-ESI-MS/MS method was successfully applied to pharmacokinetic studies of piperine and piperlonguminine in rats after oral administration of alkaloids from P. longum L. showed protective effects on Parkinson's disease models in the authors' previous study.
Journal ArticleDOI
Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson’s disease
Ying Bi,Peng-Cheng Qu,Qing-Song Wang,Li Zheng,Hao-Long Liu,Rong Luo,Xiao-Qing Chen,Yin-Ying Ba,Xia Wu,Hui Yang +9 more
TL;DR: The results indicate that PLA possesses neuroprotective effects and has ameliorative properties in dopaminergic neurons in Parkinson’s disease.
Journal ArticleDOI
Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury
TL;DR: Novel insight is provided into the neuroprotective function of PLL as well as evidence in favor of its use in PD treatment is provided, as part of a Special Issue entitled SI: Neuroprotection.