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Xiang Fu
Researcher at St. Jude Children's Research Hospital
Publications - 10
Citations - 305
Xiang Fu is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Sutherlandia frutescens & Cereblon. The author has an hindex of 5, co-authored 10 publications receiving 217 citations. Previous affiliations of Xiang Fu include University of Mississippi & Chinese Academy of Sciences.
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Journal ArticleDOI
Cycloartane glycosides from Sutherlandia frutescens.
Xiang Fu,Xing-Cong Li,Troy J. Smillie,Paulo Carvalho,Wilfred T. Mabusela,James Syce,Quinton Johnson,William R. Folk,Mitchell A. Avery,Ikhlas A. Khan +9 more
TL;DR: Four new cycloartane glycosides, sutherlandiosides A-D (1-4), were isolated from the South African folk medicine Sutherlandia frutescens and their structures established by spectroscopic methods and X-ray crystallography.
Journal ArticleDOI
Simultaneous determination of the absolute configuration of twelve monosaccharide enantiomers from natural products in a single injection by a UPLC-UV/MS method.
TL;DR: Among derivatives of sugar enantiomers in the current study, the stereoisomer of R- configuration at C-3' retained longer than the corresponding S-configuration isomer, suggesting that the UPLC-MS method can increase sensitivity of detection of the saccharides by more than 10 times compared to previously reported methods.
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Quantitative determination of flavonoids and cycloartanol glycosides from aerial parts of Sutherlandia frutescens (L.) R. BR. by using LC-UV/ELSD methods and confirmation by using LC-MS method.
Bharathi Avula,Yan-Hong Wang,Troy J. Smillie,Xiang Fu,Xing-Cong Li,Wilfred T. Mabusela,James Syce,Quinton Johnson,William R. Folk,Ikhlas A. Khan +9 more
TL;DR: This paper describes the first analytical method for the determination of four flavonoids and four cycloartanol glycosides from the aerial parts of Sutherlandia frutescens by using the use of the [M+H](+) and [M-Na](+) ions in the positive ion mode with extractive ion monitoring (EIM).
Journal ArticleDOI
Flavonol Glycosides from the South African Medicinal Plant Sutherlandia frutescens
Xiang Fu,Xing-Cong Li,Yan-Hong Wang,Bharathi Avula,Troy J. Smillie,Wilfred T. Mabusela,James Syce,Quinton Johnson,William R. Folk,Ikhlas A. Khan +9 more
TL;DR: Phytochemical investigation of the leaves of Sutherlandia frutescens led to the isolation of four new 3-hydroxy-3-methylglutaroyl-containing flavonol glycosides, sutherlandins A-D, which were elucidated by chemical and spectroscopic methods.
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Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
Gisele Nishiguchi,Fatemeh Keramatnia,Fatemeh Keramatnia,Jaeki Min,Yunchao Chang,Barbara Jonchere,Sourav Das,Marisa Actis,Jeanine E. Price,Divyabharathi Chepyala,Brandon Young,Kevin McGowan,P. Jake Slavish,Anand Mayasundari,Jamie Jarusiewicz,Lei Yang,Yong Li,Xiang Fu,Shalandus H. Garrett,James B Papizan,Kiran Kodali,Junmin Peng,Shondra Miller,Martine F. Roussel,Charles G. Mullighan,Marcus Fischer,Marcus Fischer,Zoran Rankovic +27 more
TL;DR: In this article, the authors describe the design, synthesis, and screening of a large diverse library of thalidomide analogues against a panel of patient-derived leukemia and medulloblastoma cell lines.