J
Junmin Peng
Researcher at St. Jude Children's Research Hospital
Publications - 272
Citations - 27513
Junmin Peng is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 74, co-authored 229 publications receiving 23664 citations. Previous affiliations of Junmin Peng include Howard Hughes Medical Institute & Emory University.
Papers
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Journal ArticleDOI
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
TL;DR: The combination of strong cation exchange (SCX) and reversed-phase (RP) chromatography to achieve two-dimensional separation prior to MS/MS and 1,504 yeast proteins were unambiguously identified in this single analysis.
Journal ArticleDOI
A proteomics approach to understanding protein ubiquitination
Junmin Peng,Junmin Peng,Daniel Schwartz,Joshua E. Elias,Carson C. Thoreen,Dongmei Cheng,Gerald T. Marsischky,Jeroen Roelofs,Daniel Finley,Steven P. Gygi +9 more
TL;DR: A proteomics approach to enrich, recover, and identify ubiquitin conjugates from Saccharomyces cerevisiae lysate provides a general tool for the large-scale analysis and characterization of protein ubiquitination.
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Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.
Ping Xu,Duc M. Duong,Nicholas T. Seyfried,Dongmei Cheng,Yang Xie,Jessica Robert,John Rush,Mark Hochstrasser,Daniel Finley,Junmin Peng +9 more
TL;DR: It is reported that the unconventional linkages are abundant in vivo and that all non-K63 linkages may target proteins for degradation, and that unconventional polyubiquitin chains are critical for ubiquitin-proteasome system function.
Journal ArticleDOI
Neurotoxicity induces cleavage of p35 to p25 by calpain
TL;DR: Observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease.
Journal ArticleDOI
Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro
Yuerong Zhu,T Pe'ery,Junmin Peng,Yegnanarayana Ramanathan,Nick F. Marshall,Tricia K. Marshall,Brad A. Amendt,Michael B. Mathews,David H. Price +8 more
TL;DR: The cloning of the small subunit of Drosophila P-TEFb and the finding that it encodes a Cdc2-related protein kinase is reported, indicating that P- TEFb is a Tat-associated kinase (TAK) and PITALRE associated with the activation domain of HIV-1 Tat.