Xiangfeng Li

TL;DR: An implant combined with both antitumor and bone regeneration functions is developed, showing a prominent effect in suppressing tumor growth and osteolytic lesion but also promoted bone regeneration and provides a rationale for using n-HA in tumor-associated bone segmental defects.

TL;DR: It is indicated that CaP ceramics with different phase composition could present divergent osteoinductive capacities through modulating polarization and functional status of macrophages, as biphasic calcium phosphate with potent osteoInductivity ameliorated long-term inflammation and induced a healing-associated M2 phenotype to initiate bone formation.

TL;DR: Due to nanotopographic similarities with nature bone apatite, BCP-N has excellent efficacy in guiding bone regeneration and holds great potential to become a potential alternative to standard bone grafts in bone defect filling applications.

TL;DR: The present study provided an optimized formula to fabricate osteoinductive calcium phosphate (CaP) ceramics with high precision and controllable three-dimensional (3D) structure that could have good potential in customized bone-repairing applications.

TL;DR: It is demonstrated that the surface structure of CaP ceramics has a great influence on osteoclastogenesis, which might be further related to its osteoinductive capacity.