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Xianzheng Zhou
Researcher at University of Minnesota
Publications - 14
Citations - 1044
Xianzheng Zhou is an academic researcher from University of Minnesota. The author has contributed to research in topics: Sleeping Beauty transposon system & Transposase. The author has an hindex of 9, co-authored 11 publications receiving 979 citations. Previous affiliations of Xianzheng Zhou include University of Pennsylvania.
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Journal ArticleDOI
miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1
Changming Lu,Xin Huang,Xiaoxiao Zhang,Kristin Roensch,Qing Cao,Keiichi I. Nakayama,Bruce R. Blazar,Yan Zeng,Xianzheng Zhou +8 more
TL;DR: This study uncovered miRNA signatures during monocyte differentiation into DCs and the new regulatory role of miR-221 and miR -155 in DC apoptosis and IL-12p70 production and provides evidence thatmiR-155 indirectly regulated p27(kip1) protein level by targeting Kip1 ubiquitination-promoting complex 1.
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Gene Transfer Efficiency and Genome-Wide Integration Profiling of Sleeping Beauty, Tol2, and PiggyBac Transposons in Human Primary T Cells
Xin Huang,Hongfeng Guo,Syam Tammana,Yong Chul Jung,Emil Mellgren,Preetinder Bassi,Qing Cao,Zheng Jin Tu,Yeong C. Kim,Stephen C. Ekker,Xiaolin Wu,San Ming Wang,Xianzheng Zhou +12 more
TL;DR: Results suggest that Sleeping Beauty may be a preferential choice of the delivery vector in T cells due to its random integration site preference and relatively high efficiency, and support continuing development of SB-mediated T-cell phase I trials.
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4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies.
Syam Tammana,Xin Huang,Marianna Wong,Michael C. Milone,Linan Ma,Bruce L. Levine,Carl H. June,John E. Wagner,Bruce R. Blazar,Xianzheng Zhou +9 more
TL;DR: The data suggest a synergistic role of 4-1BB and CD28 costimulation in engineering antileukemia UCB effector cells and implicate a design for redirected UCB T-cell therapy for refractory leukemia.
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Sleeping Beauty Transposon‐mediated Engineering of Human Primary T Cells for Therapy of CD19+ Lymphoid Malignancies
Xin Huang,Hongfeng Guo,Johnthomas Kang,Suet Choi,Tom C. Zhou,Syam Tammana,Christopher J. Lees,Zhong Ze Li,Michael C. Milone,Bruce L. Levine,Jakub Tolar,Carl H. June,R. Scott McIvor,John E. Wagner,Bruce R. Blazar,Xianzheng Zhou +15 more
TL;DR: Data indicate that T cells from PB and UCB can be stably modified using a non-viral DNA transfer system, and that such modified T cells may be useful in the treatment of refractory leukemia and lymphoma.
Journal ArticleDOI
Stable gene transfer and expression in cord blood–derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system
Xingkui Xue,Xin Huang,Sonja E. Nodland,Lajos Mátés,Linan Ma,Zsuzsanna Izsvák,Zoltán Ivics,Tucker W. LeBien,R. Scott McIvor,John E. Wagner,Xianzheng Zhou +10 more
TL;DR: Stable gene transfer in cord blood-derived CD34(+) hematopoietic stem cells using a hyperactive nonviral Sleeping Beauty (SB) transposase (SB100X) and integration site analysis revealed SB transposon sequences in the human chromosomes of in vitro differentiated T, B, NK, and myeloid cells, as well as in human CD45(+) cells isolated from bone marrow and spleen of transplanted NOG mice.