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Xiao Yu
Researcher at Imperial College London
Publications - 33
Citations - 1455
Xiao Yu is an academic researcher from Imperial College London. The author has contributed to research in topics: Non-rapid eye movement sleep & Sleep deprivation. The author has an hindex of 16, co-authored 29 publications receiving 1087 citations. Previous affiliations of Xiao Yu include Nanjing Normal University & University of Zurich.
Papers
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Journal ArticleDOI
Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists.
Zhe Zhang,Valentina Ferretti,İlke Güntan,Alessandro Moro,Eleonora A Steinberg,Zhiwen Ye,Anna Y. Zecharia,Xiao Yu,Alexei L. Vyssotski,Stephen G. Brickley,Raquel Yustos,Zoe Pillidge,Edward C. Harding,William Wisden,Nicholas P. Franks +14 more
TL;DR: It is found that α2 adrenergic receptor–induced sedation and recovery sleep share hypothalamic circuitry sufficient for producing these behavioral states: the preoptic hypothalamic area and locus coeruleus area, respectively.
Journal ArticleDOI
GABA and glutamate neurons in the VTA regulate sleep and wakefulness
Xiao Yu,Wen Li,Ying Ma,Kyoko Tossell,Julia J. Harris,Julia J. Harris,Edward C. Harding,Wei Ba,Giulia Miracca,Dan Wang,Long Li,Juan Guo,Ming Chen,Yuqi Li,Raquel Yustos,Alexei L. Vyssotski,Denis Burdakov,Qianzi Yang,Hailong Dong,Nicholas P. Franks,William Wisden +20 more
TL;DR: It is suggested that GABAergic VTA neurons may limit wakefulness by inhibiting the arousal-promoting VTA glutamatergic and/or dopaminergic neurons and through projections to the lateral hypothalamus and nucleus accumbens.
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Wakefulness Is Governed by GABA and Histamine Cotransmission
Xiao Yu,Zhiwen Ye,Catriona M. Houston,Anna Y. Zecharia,Ying Ma,Zhe Zhang,David S. Uygun,Susan Parker,Alexei L. Vyssotski,Raquel Yustos,Nicholas P. Franks,Stephen G. Brickley,William Wisden +12 more
TL;DR: Wake-active histaminergic neurons generate a paracrine GABAergic signal that serves to provide a brake on overactivation from histamine, but could also increase the precision of neocortical processing.
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Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice
TL;DR: The data suggest that CGA has remarkable hepatoprotective effects on LPS-induced liver injury and that the possible mechanism is related to its anti-inflammatory action.
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A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus
Edward C. Harding,Xiao Yu,Andawei Miao,Nathanael Andrews,Ying Ma,Zhiwen Ye,Leda Lignos,Giulia Miracca,Wei Ba,Raquel Yustos,Alexei L. Vyssotski,William Wisden,Nicholas P. Franks +12 more
TL;DR: Embedded circuitry explains how skin warming induces sleep and why the maximal rate of core body cooling positively correlates with sleep onset, and implies that one function of NREM sleep is to lower brain temperature and/or conserve energy.