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Xiaochuan Sun
Researcher at Chongqing Medical University
Publications - 152
Citations - 2602
Xiaochuan Sun is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Traumatic brain injury & Medicine. The author has an hindex of 22, co-authored 123 publications receiving 1821 citations. Previous affiliations of Xiaochuan Sun include Loma Linda University & Harvard University.
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Journal ArticleDOI
Controversies and evolving new mechanisms in subarachnoid hemorrhage.
Sheng Chen,Hua Feng,Prativa Sherchan,Damon Klebe,Gang Zhao,Xiaochuan Sun,Jianmin Zhang,Jiping Tang,John H. Zhang +8 more
TL;DR: The vast array of physiological dysfunctions following SAH that ultimately lead to cell death are discussed and a new concept of the vasculo-neuronal-glia triad model for SAH study is highlighted and presents the challenges and opportunities of this model for future SAH applications.
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Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats
Zongduo Guo,Qin Hu,Liang Xu,Zhen-Ni Guo,Yi-bo Ou,Yue He,Cheng Yin,Xiaochuan Sun,Jiping Tang,John H. Zhang +9 more
TL;DR: Exogenous LXA4 decreased brain water content, reduced Evans blue extravasation, and improved neurological functions and improved the learning and memory ability after SAH, suggesting it may serve as an alternative treatment to relieve early brain injury afterSAH.
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The long non-coding RNA Neat1 is an important mediator of the therapeutic effect of bexarotene on traumatic brain injury in mice
Jianjun Zhong,Li Jiang,Zhijian Huang,Hongrong Zhang,Chongjie Cheng,Han Liu,Junchi He,Jingchuan Wu,Rami Darwazeh,Yue Wu,Xiaochuan Sun +10 more
TL;DR: The in vitro anti-apoptotic and anti-inflammatory effects of Neat1 were further confirmed in C57BL/6 mice, which resulted in better functional recovery in mice after TBI.
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Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.
Jinwei Pang,Yitian Chen,Li Kuai,Ping Yang,Jianhua Peng,Yue Wu,Yue Chen,Michael P. Vitek,Ligang Chen,Xiaochuan Sun,Yong Jiang +10 more
TL;DR: Investigation revealed that the ApoE-mimetic peptide inhibited the proinflammatory activators of MMP-9, including CypA, NF-κB, IL-6, TNF-α, and IL-1β, thereby ameliorating BBB disruption at the acute stage of SAH.
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Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice.
Jinwei Pang,Jianhua Peng,Nathanael Matei,Ping Yang,Li Kuai,Yue Wu,Ligang Chen,Michael P. Vitek,Michael P. Vitek,Fengqiao Li,Xiaochuan Sun,John H. Zhang,Yong Jiang +12 more
TL;DR: ApoE and apoE-mimetic peptide have whole-brain protective effects that may reduce EBI after SAH via M1 microglial quiescence through the attenuation of the JAK2/STAT3/NOX2 signaling pathway axis.