J
John H. Zhang
Researcher at Loma Linda University
Publications - 936
Citations - 36397
John H. Zhang is an academic researcher from Loma Linda University. The author has contributed to research in topics: Subarachnoid hemorrhage & Neuroprotection. The author has an hindex of 84, co-authored 895 publications receiving 29976 citations. Previous affiliations of John H. Zhang include University of Mississippi & Zhejiang University.
Papers
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Journal ArticleDOI
Mechanisms of early brain injury after subarachnoid hemorrhage
TL;DR: Experimental data suggest that the apoptotic cascades occur very early after the initial insult and may be related directly to physiologic sequela commonly associated with SAH.
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A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model.
TL;DR: A simple and objective novel SAH grading system is outlined by examining the subarachnoid blood clots in the basal cisterns, and evaluating for correlation with neurological status and cerebral vasospasm and effects of simvastatin were examined.
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The importance of early brain injury after subarachnoid hemorrhage
TL;DR: Early brain injury after aSAH is reviewed with a review of animal models of early brain injury, the mechanisms of brain injury according to the sequence of their temporal appearance are reviewed and the failure of clinical translation of therapies successful in animal models are discussed.
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Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research
Mutsumi Fujii,Junhao Yan,William B. Rolland,Yoshiteru Soejima,Basak Caner,John H. Zhang,John H. Zhang +6 more
TL;DR: It could be argued that the treatment of EBI may successfully attenuate some of the devastating secondary injuries and improve the outcome of patients with SAH and the reversal of vasospasm does not appear to improve patient outcome.
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Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought.
Ryszard M. Pluta,Jacob Hansen-Schwartz,Jens P. Dreier,Peter Vajkoczy,R. Loch Macdonald,Shigeru Nishizawa,Hideotoshi Kasuya,George C. Wellman,Emanuela Keller,Alois Zauner,Nicholas Dorsch,Joseph Clark,Shigeki Ono,Talat Kiris,Peter LeRoux,John H. Zhang +15 more
TL;DR: A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity.