Xiaodong Ren

TL;DR: The present review surveys the pharmacological advantages and deficiencies of both reversible and irreversible BTK drugs, with a focus on the structure-activity relationship (SARs) and binding modes of representative drugs, which could inspire critical thinking and new ideas for developing potent BTK inhibitors with less unwanted off-target effects.

TL;DR: This review describes the promising RdRp inhibitors that have been launched or are currently in clinical studies for the treatment of RNA virus infections and suggests more precise guidelines for the development of more promising anti-RNA virus drugs should be set.

TL;DR: 3CLpro PROTAC degraders are hypothesised to be next-generation anti-coronavirus drugs based on the emerging PROTAC technology and the existing 3CLpro inhibitors.

TL;DR: In this article, a comprehensive overview of the clinical progress on and the molecular mechanisms of ATRA in the treatment of acute promyelocytic leukaemia (APL) is provided.

TL;DR: Wang et al. as mentioned in this paper conducted a comprehensive review of the active ingredients in LH capsules and provided a summary of the potential molecular mechanisms of specific substances in the capsules involved in resistance to SARS-COV-2 infection and inhibition of cytokine storm syndrome (CSS) caused by IL-6.