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Xiaodong Zhou
Researcher at St. Jude Children's Research Hospital
Publications - 4
Citations - 2564
Xiaodong Zhou is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Gene expression profiling & Erg. The author has an hindex of 3, co-authored 4 publications receiving 2502 citations. Previous affiliations of Xiaodong Zhou include University UCINF.
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Journal ArticleDOI
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Eng Juh Yeoh,Mary E. Ross,Sheila A. Shurtleff,W. Kent Williams,Divyen H. Patel,Rami Mahfouz,Frederick G. Behm,Susana C. Raimondi,Mary V. Relling,Anami Patel,Cheng Cheng,Dario Campana,Dawn Wilkins,Xiaodong Zhou,Jinyan Li,Huiqing Liu,Ching-Hon Pui,William E. Evans,Clayton W. Naeve,Limsoon Wong,James R. Downing +20 more
TL;DR: Oligonucleotide microarrays used to analyze the pattern of genes expressed in leukemic blasts from 360 pediatric ALL patients identified each of the prognostically important leukemia subtypes, and within some genetic subgroups, expression profiles identified those patients that would eventually fail therapy.
Journal ArticleDOI
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
Mary E. Ross,Xiaodong Zhou,Guangchun Song,Sheila A. Shurtleff,Kevin Girtman,W. Kent Williams,Hsi Che Liu,Rami Mahfouz,Susana C. Raimondi,Noel Lenny,Anami Patel,James R. Downing +11 more
TL;DR: Analysis of leukemic blasts from 132 diagnostic samples using higher density oligonucleotide arrays revealed new insights into the altered biology underlying these leukemias, including T-cell lineage ALL and hyperdiploid karyotypes with more than 50 chromosomes.
Journal ArticleDOI
ERG Deletions Define a Novel Subtype of B-Progenitor Acute Lymphoblastic Leukemia.
Charles G. Mullighan,Christopher B. Miller,Xiaoping Su,Ina Radtke,James Dalton,Guanchung Song,Xiaodong Zhou,Ching-Hon Pui,Sheila A. Shurtleff,James R. Downing +9 more
TL;DR: F focal ERG deletions are established as the genetic lesion underlying a novel subtype of ALL, and the genetic mechanisms that lead to the dysregulation of ERG are expanded from chromosomal translocations that result in enhanced transcriptional activity, to deletions that generate dominant negative forms of the transcription factor.
Journal ArticleDOI
Pediatric Acute Myeloid Leukemia with Nucleophosmin Mutations Is Characterized by a Gene Expression Signature with Dysregulated HOX Gene Expression Distinct from MLL-Rearranged Leukemias.
TL;DR: The hypothesis that mutated NPM dysregulates HOX expression via a different mechanism than MLL rearrangement is supported, and the first evidence that the NPM m+ signature is similar to but distinct from MLL- rearranged AML is provided.