S
Sheila A. Shurtleff
Researcher at St. Jude Children's Research Hospital
Publications - 125
Citations - 22699
Sheila A. Shurtleff is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 59, co-authored 123 publications receiving 20519 citations. Previous affiliations of Sheila A. Shurtleff include University of Tennessee Health Science Center.
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Journal ArticleDOI
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Eng Juh Yeoh,Mary E. Ross,Sheila A. Shurtleff,W. Kent Williams,Divyen H. Patel,Rami Mahfouz,Frederick G. Behm,Susana C. Raimondi,Mary V. Relling,Anami Patel,Cheng Cheng,Dario Campana,Dawn Wilkins,Xiaodong Zhou,Jinyan Li,Huiqing Liu,Ching-Hon Pui,William E. Evans,Clayton W. Naeve,Limsoon Wong,James R. Downing +20 more
TL;DR: Oligonucleotide microarrays used to analyze the pattern of genes expressed in leukemic blasts from 360 pediatric ALL patients identified each of the prognostically important leukemia subtypes, and within some genetic subgroups, expression profiles identified those patients that would eventually fail therapy.
Journal ArticleDOI
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
Charles G. Mullighan,Salil Goorha,Ina Radtke,Christopher B. Miller,Elaine Coustan-Smith,James Dalton,Kevin Girtman,Susan Mathew,Jing Ma,Stanley Pounds,Xiaoping Su,Ching-Hon Pui,Mary V. Relling,William E. Evans,Sheila A. Shurtleff,James R. Downing +15 more
TL;DR: It is suggested that direct disruption of pathways controlling B-cell development and differentiation contributes to B-progenitor ALL pathogenesis and the power of high-resolution, genome-wide approaches to identify new molecular lesions in cancer.
Journal ArticleDOI
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Jinghui Zhang,Li Ding,Linda Holmfeldt,Gang Wu,Susan L. Heatley,Susan L. Heatley,Debbie Payne-Turner,John Easton,Xiang Chen,Jianmin Wang,Michael Rusch,Charles Lu,Shann Ching Chen,Lei Wei,J. Racquel Collins-Underwood,Jing Ma,Kathryn G. Roberts,Stanley Pounds,Anatoly Ulyanov,Jared Becksfort,Pankaj Gupta,Robert Huether,Richard W. Kriwacki,Matthew Parker,Daniel J. McGoldrick,David Zhao,Daniel Alford,Stephen Espy,Kiran Chand Bobba,Guangchun Song,Deqing Pei,Cheng Cheng,Stefan Roberts,Michael I. Barbato,Michael I. Barbato,Dario Campana,Dario Campana,Elaine Coustan-Smith,Elaine Coustan-Smith,Sheila A. Shurtleff,Susana C. Raimondi,Maria Kleppe,Maria Kleppe,Jan Cools,Kristin A. Shimano,Michelle L. Hermiston,Sergei Doulatov,Kolja Eppert,Elisa Laurenti,Faiyaz Notta,John E. Dick,Giuseppe Basso,Stephen P. Hunger,Mignon L. Loh,Meenakshi Devidas,Brent L. Wood,Stuart S. Winter,Kimberley P. Dunsmore,Robert S. Fulton,Lucinda Fulton,Xin Hong,Chris Harris,David J. Dooling,Kerri Ochoa,Kimberly J. Johnson,John C. Obenauer,William E. Evans,Ching-Hon Pui,Clayton W. Naeve,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Charles G. Mullighan +73 more
TL;DR: The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL.
Journal ArticleDOI
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.
Charles G. Mullighan,Xiaoping Su,Jinghui Zhang,Ina Radtke,Letha A. Phillips,Christopher B. Miller,Jing Ma,Wei Liu,Cheng Cheng,Brenda A. Schulman,Brenda A. Schulman,Richard C. Harvey,Richard C. Harvey,I-Ming Chen,I-Ming Chen,Robert J. Clifford,William L. Carroll,Gregory H. Reaman,W. Paul Bowman,Meenakshi Devidas,Daniela S. Gerhard,Wenjian Yang,Mary V. Relling,Sheila A. Shurtleff,Dario Campana,Michael J. Borowitz,Ching-Hon Pui,Malcolm A. Smith,Stephen P. Hunger,Cheryl L. Willman,Cheryl L. Willman,James R. Downing +31 more
TL;DR: In this paper, a cohort of 221 children with high-risk B-cell-progenitor ALL with the use of single-nucleotide-polymorphism microarrays, transcriptional profiling, and resequencing of samples obtained at diagnosis were studied.
Journal ArticleDOI
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.
Dawn E. Quelle,Richard A. Ashmun,Sheila A. Shurtleff,Jun-ya Kato,Dafna Bar-Sagi,Martine F. Roussel,Charles J. Sherr +6 more
TL;DR: Mammalian D-type cyclins are growth factor-regulated, delayed early response genes that are presumed to control progression through the G1 phase of the cell cycle by governing the activity of cyclin-dependent kinases, and cyclin D1, and most likely D2, are rate limiting for G1 progression.