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Xiaofeng Yang
Researcher at University of Illinois at Chicago
Publications - 7
Citations - 252
Xiaofeng Yang is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Catechol-O-methyl transferase & Protein disulfide-isomerase. The author has an hindex of 6, co-authored 7 publications receiving 244 citations.
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Journal ArticleDOI
Enhanced Ionization of Phosphorylated Peptides during MALDI TOF Mass Spectrometry
TL;DR: 2',4',6'-trihydroxyacetophenone (THAP) with diammonium citrate was found to overcome the problem of suppressing the ionization of phosphorylated peptides in matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF) mass spectrometry.
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A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: Identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C
TL;DR: This report describes a method to determine the phosphorylation states of cTnI with non-equilibrium isoelectric focusing gel electrophoresis (NEIEF), and identifies Ser-23 and Ser-24 (normally considered to be PKA-dependent sites) as substrates for phosphorylated by PKC-beta and PKC -epsilon.
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Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study.
TL;DR: In this paper, a COATag (covert oxidatively activated tag) was synthesized in which raloxifene was linked to biotin and was reactive toward a human glutathione-S-transferase P1-1, in the presence but not the absence of monooxygenase.
Analysis of Protein Covalent Modification by Xenobiotics using a Covert Oxidatively Activated Tag
TL;DR: The combined use of a COATag with a simple biotin-linked electrophile is a new technique that allows quantification of protein covalent modification via alkylation vs oxidation in response to xenobiotic reactive intermediates.
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Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase
Jiaqin Yao,Yan Li,Minsun Chang,Huaping Wu,Xiaofeng Yang,Julie E. Goodman,Xuemei Liu,Hong Liu,Andrew D. Mesecar,Richard B. van Breemen,James D. Yager,Judy L. Bolton +11 more
TL;DR: In conclusion, inhibition of COMT methylation by 4-OHEN might reduce endogenous catechol estrogen clearance in vivo and further enhance toxicity.