Y
Yan Li
Researcher at University of Illinois at Chicago
Publications - 10
Citations - 165
Yan Li is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Estrogen & Catechol-O-methyl transferase. The author has an hindex of 8, co-authored 9 publications receiving 159 citations.
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Journal ArticleDOI
Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.
Xuemei Liu,Emily Pisha,Debra A. Tonetti,Dan Yao,Yan Li,Jiaqin Yao,Joanna E. Burdette,Judy L. Bolton +7 more
TL;DR: The formation of catechols represents a minor role in cytotoxic and antiestrogenic effects in cells as compared with their phenol analogues, which implies that o-quinones formed from catechol estrogens could contribute to genotoxicity in vivo, which is ER-dependent.
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Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression.
TL;DR: The involvement of other genes important in cell transformation and oxidative stress are shown, strengthening the hypothesis that this mechanism plays a considerable role in 4-OHEN-induced anchorage-independent growth.
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Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase
Jiaqin Yao,Yan Li,Minsun Chang,Huaping Wu,Xiaofeng Yang,Julie E. Goodman,Xuemei Liu,Hong Liu,Andrew D. Mesecar,Richard B. van Breemen,James D. Yager,Judy L. Bolton +11 more
TL;DR: In conclusion, inhibition of COMT methylation by 4-OHEN might reduce endogenous catechol estrogen clearance in vivo and further enhance toxicity.
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Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1.
Jiaqin Yao,Minsun Chang,Yan Li,Emily Pisha,Xuemei Liu,Dan Yao,Ebrahim C. Elguindi,Sylvie Y. Blond,Judy L. Bolton +8 more
TL;DR: 4-OHEN caused significant decreases in GST activity in nontransformed human breast epithelial cells (MCF-10A) but not in the human hepatoma HepG2 cells, which lack GST P1-1, and other cellular enzymes including PR, PK, GR, SOD, catalase, TR, and GPX were resistant to 4-OHen-induced inhibition.
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Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.
Xuemei Liu,Fagen Zhang,Hong Liu,Joanna E. Burdette,Yan Li,Cassia R. Overk,Emily Pisha,Jiaqin Yao,Richard B. van Breemen,Steven M. Swanson,Judy L. Bolton +10 more
TL;DR: The 4-fluoroequilenin derivatives have promise as alternatives to traditional estrogen replacement therapy due to their similar estrogenic properties with less overall toxicity.