Xiaojun Xu

TL;DR: It is found that animal cells are poised to respond to both increases and decreases in C18:0 levels, with increased C 18:0 dietary intake boosting mitochondrial fusion in vivo and countering the mitochondrial dysfunction caused by genetic defects such as loss of the Parkinson’s disease genes Pink or Parkin in Drosophila.

TL;DR: In this paper, the transketolase-like protein 1 (TKTL1) was inhibited by RNAi technologies in human HCT116 colon carcinoma cells, which resulted in a significantly slowed cell growth, glucose consumption and lactate production.

TL;DR: It is shown here that an additional, important regulated step is the activation of fatty acids for beta-oxidation via Acyl Co-A synthetases (ACS), and a mechanistic link through which insulin regulates lipid homeostasis is identified.

TL;DR: The results indicate that the PERK/eIF2α pathway plays an important role in 6-shogaol-mediated ER stress and apoptosis in SMMC-7721 cells in vitro and in vivo.

TL;DR: This work answers the key question of which are real bioactive components for CP that have been used in clinic for many years, and provides a promising approach for discovering BECCs from herbal medicines.