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Xiaorong Pan
Researcher at Shanghai Jiao Tong University
Publications - 16
Citations - 657
Xiaorong Pan is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Epidermal growth factor receptor & Antigen. The author has an hindex of 11, co-authored 16 publications receiving 533 citations. Previous affiliations of Xiaorong Pan include Duke University.
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Journal ArticleDOI
Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Huiping Gao,Kesang Li,Hong Tu,Xiaorong Pan,Hua Jiang,Bizhi Shi,Juan Kong,Hongyang Wang,Shengli Yang,Jianren Gu,Zonghai Li +10 more
TL;DR: GPC3-targeted CAR T cells could potently eliminate G PC3-positive HCC cells, thereby providing a promising therapeutic intervention for GPC2- positive HCC, and positively correlated with GPC3 expression levels in the target cells.
Journal ArticleDOI
Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma.
Cheng Chen,Kesang Li,Hua Jiang,Fei Song,Huiping Gao,Xiaorong Pan,Bizhi Shi,Yanyu Bi,Huamao Wang,Hongyang Wang,Hongyang Wang,Zonghai Li +11 more
TL;DR: Together, T cells carrying two complementary CARs against GPC3 and ASGR1 may reduce the risk of on-target, off-tumor toxicity while maintaining relatively potent antitumor activities on G PC3+ASGR1+ HCC.
Journal ArticleDOI
Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells.
Kelong Ma,Kelong Ma,Kelong Ma,Xiaorong Pan,Pingsheng Fan,Yinghua He,Jun Gu,Wei Wang,Tengyue Zhang,Zonghai Li,Xiaoying Luo +10 more
TL;DR: It is demonstrated that the loss of miR-638 promotes invasion and a mesenchymal-like transition by directly targeting SOX2 in vitro and is defined as a new, invasion-associated tumor suppressor of CRC.
Journal ArticleDOI
EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer
Jiqin Zhang,Jiqin Zhang,Fei Song,Xiaojing Zhao,Hua Jiang,Xiuqi Wu,Biao Wang,Min Zhou,Mi Tian,Bizhi Shi,Huamao Wang,Yuanhui Jia,Hai Wang,Hai Wang,Hai Wang,Xiaorong Pan,Zonghai Li +16 more
TL;DR: This study demonstrates that EGFR stabilizes SCD1 through Y55 phosphorylation, thereby up-regulating MUFA synthesis to promote lung cancer growth and proposes SCD 1 Y55osphorylation as a potential diagnostic marker for lung cancer.
Journal ArticleDOI
EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1.
Biao Wang,Jiqin Zhang,Fei Song,Mi Tian,Bizhi Shi,Hua Jiang,Wen Xu,Hai Wang,Min Zhou,Xiaorong Pan,Jianren Gu,Shengli Yang,Liyan Jiang,Zonghai Li +13 more
TL;DR: It is reported that epidermal growth factor receptor (EGFR), an oncogenic driver, binds to and regulates the subcellular distribution of transferrin receptor 1(TfR1) through its tyrosine kinase activity and thus is required for cellular iron import.