Xiaotong Luo

TL;DR: A software package called illustrator of biological sequences (IBS) that can be used for representing the organization of either protein or nucleotide sequences in a convenient, efficient and precise manner.

TL;DR: In this paper, the RNA methyltransferase METTL3 is activated by ATM-mediated phosphorylation at S43, where it methylates the N6 position of adenosine (m6A) in DNA damage-associated RNAs, which recruits the m6A reader protein YTHDC1 for protection.

TL;DR: A systematic analysis of the co-regulatory mechanism between different lipid modifications with GPS-Lipid demonstrated that the proximal dual-lipid modifications among palmitoylation, myristoylation and prenylation are key mechanism for regulating various protein functions.

TL;DR: An updated version of m6AVar, developed to host all RNA modification (RM)-associated variants, is presented, renamed RMVar, and it is expected that RMVar may boost further functional studies on genetic variants affecting RNA modifications.

TL;DR: The application of deep learning method and novel encoding schemes, especially the position-specific scoring feature, greatly improves the accuracy of nitration and nitrosylation site prediction and may facilitate the prediction of other PTM sites.