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Xiaoxiang Liu
Researcher at University of Wisconsin–Milwaukee
Publications - 17
Citations - 490
Xiaoxiang Liu is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Total synthesis & Indole test. The author has an hindex of 11, co-authored 17 publications receiving 465 citations. Previous affiliations of Xiaoxiang Liu include United States Naval Research Laboratory.
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Journal ArticleDOI
Efficient asymmetric synthesis of biologically important tryptophan analogues via a palladium-mediated heteroannulation reaction.
TL;DR: The optically pure 6-methoxy-D-tryptophan 62 was prepared by this protocol on a large scale and should permit entry into many ring-A oxygenated indole alkaloids when coupled with the asymmetric Pictet-Spengler reaction.
Journal ArticleDOI
Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.
Hiteshkumar D. Jain,Chunchun Zhang,Shuo Zhou,Hao Zhou,Jun Ma,Xiaoxiang Liu,Xuebin Liao,Amy M. Deveau,Christine M. Dieckhaus,Michael A. Johnson,Kirsten S. Smith,Timothy L. Macdonald,Hideaki Kakeya,Hiroyuki Osada,James M. Cook +14 more
TL;DR: SAR studies resulted in the identification of the essential structural features required for cytotoxic activity of tryprostatin A analogues, and these analogues were assayed for their growth inhibition properties and their ability to perturb the cell cycle in tsFT210 cells.
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Regiospecific, Enantiospecific Total Synthesis of the Alkoxy-Substituted Indole Bases, 16-epi-Na-Methylgardneral, 11-Methoxyaffinisine, and 11-Methoxymacroline as Well as the Indole Alkaloids Alstophylline and Macralstonine
TL;DR: The key C-19 ketosarpagine system (borane adducts) employed for the construction of 11-methoxymacroline was also transformed into alstophylline 25, which resulted in completion of the total synthesis of the bisindole macralstonine.
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Concise synthesis of optically active ring-a substituted tryptophans
TL;DR: A concise synthesis of optically active trytophan derivatives was developed via diastereoselective alkylation of the Schollkopf chiral auxiliary to provide alkyne which underwent palladium-catalyzed heteroannulation with iodoanilines 1 to furnish protected tryptophans 12 in good yields.
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Stereocontrolled total synthesis of alkaloid G via the oxy-anion Cope rearrangement and improved total synthesis of (+)-ajmaline.
TL;DR: The oxy-anion Cope rearrangement followed by protonation of the enolate has been employed to generate the key asymmetric centers at C(15), C(16), and C(20) in alkaloid G (1) and (+)-ajmaline (2) in a highly stereocontrolled fashion.