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Xiaoxiao Wang
Researcher at Chinese Academy of Sciences
Publications - 11
Citations - 311
Xiaoxiao Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Embryonic stem cell & Epiblast. The author has an hindex of 7, co-authored 7 publications receiving 154 citations.
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Journal ArticleDOI
In vitro culture of cynomolgus monkey embryos beyond early gastrulation
Huaixiao Ma,Huaixiao Ma,Jinglei Zhai,Haifeng Wan,Xiangxiang Jiang,Xiaoxiao Wang,Lin Wang,Yunlong Xiang,Xiechao He,Zhen-Ao Zhao,Bo Zhao,Ping Zheng,Ping Zheng,Lei Li,Hongmei Wang +14 more
TL;DR: A system that supports the growth of cynomolgus monkey embryos in vitro for up to 20 days postfertilization and recapitulated key events of early primate in vivo postimplantation development is developed.
Journal ArticleDOI
Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency
Yunlong Xiang,Yu Zhang,Qianhua Xu,Chen Zhou,Bofeng Liu,Zhenhai Du,Ke Zhang,Bingjie Zhang,Xiaoxiao Wang,Srimonta Gayen,Ling Liu,Yao Wang,Yuanyuan Li,Qiujun Wang,Sundeep Kalantry,Lei Li,Wei Xie +16 more
TL;DR: The data characterize lineage-specific chromatin reconfiguration and a unique chromatin state for primed pluripotency in epiblast cells around implantation, and show that KMT2B is essential for establishing bivalent H3K4me3 at E6.5 but becomes partially dispensable later.
Journal ArticleDOI
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation.
Xiaoxiao Wang,Yunlong Xiang,Yang Yu,Ran Wang,Yu Zhang,Qianhua Xu,Sun Hao,Zhen Ao Zhao,Xiangxiang Jiang,Xiaoqing Wang,Xukun Lu,Dandan Qin,Yujun Quan,Jiaqi Zhang,Ng Shyh-Chang,Hongmei Wang,Naihe Jing,Naihe Jing,Wei Xie,Lei Li +19 more
TL;DR: In this article, self-renewing formative pluripotent stem cells (fPSCs) were established from different mouse ESCs, pre-/early-gastrula epiblasts and induced PSCs.
Journal ArticleDOI
Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes.
Shumei Miao,Dandan Zhao,Xiaoxiao Wang,Xuan Ni,Xing Fang,Miao Yu,Lingqun Ye,Jingsi Yang,Hongchun Wu,Xinglong Han,Lina Qu,Lei Li,Feng Lan,Zhenya Shen,Wei Lei,Zhen-Ao Zhao,Shijun Hu +16 more
TL;DR: It is indicated that RA treatment at an early time window (days 2-4) promotes the efficiency of cardiomyocyte differentiation and that RAtreatment post beating (days 15-20) promotes cardiomeocyte maturation.
Journal ArticleDOI
The roles of ERAS during cell lineage specification of mouse early embryonic development
Zhen-Ao Zhao,Yang Yu,Huaixiao Ma,Xiaoxiao Wang,Xukun Lu,Yanhua Zhai,Xiaoxin Zhang,Haibin Wang,Lei Li +8 more
TL;DR: A dynamic expression pattern of Eras is reported during mouse peri-implantation development: its expression increases at the blastocyst stage, and specifically decreases in E7.5 mesoderm.