Xiaoyan Deng

TL;DR: An mTagRFP-mWasabi-LC3 reporter is reported, in which mWasabi is more acid sensitive than EGFP and has no fluorescence in acidic lysosomes, and the results suggest that the dosage of chemical autophagy inducers would obviously influence autophagic flux in cells.

TL;DR: It is observed that mitochondrial reactive oxygen species (mtROS) plays an initiating role in the LOX-1/PCSK9 interaction, since mtROS induction enhanced and its inhibition reduced the expression of both PCSK9 and LOx-1.

TL;DR: The shear shining non-Newtonian nature of blood has little effect on LDL and oxygen transport in most regions of the aorta, but in the atherogenic-prone areas where luminal surface LDL concentration is high and oxygen flux is low, its effect is apparent.

TL;DR: To test the hypothesis that concentration polarization of LDL may be suppressed by the helical flow pattern in the human aorta, hence sparing the ascending aortA from atherosclerosis, the effects of aortic torsion, branching, curvature, and taper on blood flow and LDL transport in the lumen were simulated numerically under steady-state flow conditions.

TL;DR: Differential regulation of VSMC functions under two-dimensional conditions in vitro or three-dimensional co-culture conditions in vivo emphasizes the need to construct more actual environments for future research on vascular diseases and cardiovascular tissue engineering.