다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

The perspectives of regenerative medicine are still severely hampered by the host response to biomaterial implantation, despite the robustness of technologies that hold the promise to recover the functionality of damaged organs and tissues. In this scenario, the cellular and molecular events that decide on implant success and tissue regeneration are played at the interface between the foreign body and the host inflammation, determined by innate and adaptive immune responses. To avoid adverse events, rather than the use of inert scaffolds, current state of the art points to the use of immunomodulatory biomaterials and their knowledge-based use to reduce neutrophil activation, and optimize M1 to M2 macrophage polarization, Th1 to Th2 lymphocyte switch, and Treg induction. Despite the fact that the field is still evolving and much remains to be accomplished, recent research breakthroughs have provided a broader insight on the correct choice of biomaterial physicochemical modifications to tune the reaction of the host immune system to implanted biomaterial and to favor integration and healing.

/pdf/biomaterials-foreign-bodies-or-tuners-for-the-immune-4ly4hekkc1.pdf

Biomaterials: Foreign Bodies or Tuners for the Immune Response?

The surgical procedure in skin-tumor therapy usually results in cutaneous defects, and multidrug-resistant bacterial infection could cause chronic wounds. Here, for the first time, an injectable self-healing antibacterial bioactive polypeptide-based hybrid nanosystem is developed for treating multidrug resistant infection, skin-tumor therapy, and wound healing. The multifunctional hydrogel is successfully prepared through incorporating monodispersed polydopamine functionalized bioactive glass nanoparticles (BGN@ PDA) into an antibacterial F127-ε-Poly-L-lysine hydrogel. The nanocomposites hydrogel displays excellent self-healing and injectable ability, as well as robust antibacterial activity, especially against multidrug-resistant bacteria in vitro and in vivo. The nanocomposites hydrogel also demonstrates outstanding photothermal performance with (near-infrared laser irradiation) NIR irradiation, which could effectively kill the tumor cell (>90%) and inhibit tumor growth (inhibition rate up to 94%) in a subcutaneous skin-tumor model. In addition, the nanocomposites hydrogel effectively accelerates wound healing in vivo. These results suggest that the BGN-based nanocomposite hydrogel is a promising candidate for skin-tumor therapy, wound healing, and antiinfection. This work may offer a facile strategy to prepare multifunctional bioactive hydrogels for simultaneous tumor therapy, tissue regeneration, and anti-infection.

/pdf/injectable-self-healing-antibacterial-bioactive-polypeptide-22qi1q64mk.pdf

Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing

The application of hyaluronic acid in bone regeneration

The use of nanoparticles (NP) in diagnosis and treatment of many human diseases, including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the uptake efficiency significantly limit their use in clinical practice. The physico-chemical properties of NPs including surface composition, superficial charge, size and shape are considered the key factors that affect the biocompatibility and uptake efficiency of these nanoplatforms. Thanks to the possibility of modifying physico-chemical properties of NPs, it is possible to improve their biocompatibility and uptake efficiency through the functionalization of the NP surface. In this review, we summarize some of the most recent studies in which NP surface modification enhances biocompatibility and uptake. Furthermore, the most used techniques used to assess biocompatibility and uptake are also reported.

/pdf/nanoparticle-surface-functionalization-how-to-improve-1mfxwi5jdz.pdf

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization.

https://par.nsf.gov/servlets/purl/10080640

Bioactive hydrogels for bone regeneration.

Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy.

Photoluminescent hydrogels that function as both injectable scaffolds and fluorescent imaging probes hold great potential for therapeutics delivery and tissue engineering. Current fluorescent hydrogels are fabricated by either conjugating or doping a fluorescent dye, fluorescent protein, lanthanide chelate, or quantum dot into polymeric hydrogel matrix. Their biomedical applications are severely limited due to drawbacks such as photostability, carcinogenesis, and toxicity associated with the above-mentioned dopants. Here, a successful development of dopant-free photoluminescent hydrogels in situ formed by crosslinking of biocompatible polymer precursors is reported, which can be synthesized by incorporating an amino acid to a citric acid based polyester oligomer followed by functionalization of multivalent crosslinking group through a convenient transesterification reaction using Candida Antarctica Lipase B as a catalyst. It is demonstrated that the newly developed hydrogels possess tunable degradation, intrinsic photoluminescence, mechanical properties, and exhibit sustained release of various molecular weight dextrans. In vivo study shows that the hydrogels formed in situ following subcutaneous injection exhibit excellent biocompatibility and emit strong fluorescence under visible light excitation without the need of using any traditional organic dyes. Their in vivo degradation profiles are then depicted by noninvasively monitoring fluorescence intensity of the injected hydrogel implants.

Dopant-Free Hydrogels with Intrinsic Photoluminescence and Biodegradable Properties

https://doi.org/10.1016/j.bioactmat.2022.02.026

Xin Bai

Papers

Bioactive hydrogels for bone regeneration.

Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy.

Dopant-Free Hydrogels with Intrinsic Photoluminescence and Biodegradable Properties

Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy

Nanoparticle depots for controlled and sustained gene delivery.