Showing papers in "Journal of Controlled Release in 2020"

TL;DR: A comprehensive understanding of various PTAs is required for the better application of PTT in antibacterial treatment and the PTT-involved multifunctional theranostics nanoplatforms and the potential approaches for reducing the side effects are discussed.

TL;DR: An analysis of currently clinically tested, approved and marketed liposome-drug combinations provide insights into research priorities for the future of nanomedicines.

TL;DR: The main objective of this review is to report the various uses of chitosan hydrogels as drug delivery devices to control and/or delay the release of drugs loaded into their three dimensional matrix.

TL;DR: Results indicate that CBSA/siS100A4@Exosome self-assembled nanoparticles are a promising strategy to suppress postoperative breast cancer metastasis.

TL;DR: An ETPN overview of achievements in nanomedicine serves to reinforce the drive towards further expanding and growing the maturity of nanomediine for global healthcare, accelerating the pace of transformation of its great potential into tangible medical breakthroughs.

TL;DR: This study investigates and analyzes drug delivery and release strategies in the nanoparticle-based treatment of cancer, both mathematically and clinically.

TL;DR: This review addresses the current status, chemical compositions, advantages and disadvantages, toxicity and most importantly the future directions for the delivery of iron oxide based substances across the blood-brain barrier for targeting, imaging and therapy of primary and metastatic tumors of the brain.

TL;DR: This review focuses upon modifications on the exosomal surface, the chemistry involved and their impact on targeted drug delivery for the treatment of brain, breast, lung, liver, colon tumors and, heart diseases and for understanding their in vivo fate including their uptake mechanisms, pharmacokinetics and biodistribution.

TL;DR: This review systematically covers the most recent advances of DDS applicable by topical instillation, that have shown better performance on in vivo models compared to standard eye drop formulations.

TL;DR: This approach based on targeting the poorly oxygenated tumor habitats offers the prospective to overcome the difficulties that arises due to heterogenic nature of tumor and could be possibly used in the design of diagnostic as well as therapeutic nanocarriers for targeting various types of solid cancers.

TL;DR: Results indicate that T7-exo is an efficient carrier of AMO-21 into the glioblastoma and may be useful in development of gliOBlastoma therapy.

TL;DR: The in vivo gene delivery mediated by non-viral vectors to treat cancer in different tissue and organs including brain, breast, lung, liver, stomach, and prostate is highlighted and the state-of-the-art and promising perspective of in vitro gene editing using non-Viral nano-vectors is delineated.

TL;DR: This review summarizes adsorption, covalent conjugation and biotin-avidin interaction, while discussing the advantages, limitations and relevant therapeutic approaches currently under investigation.

TL;DR: The application of nanomedicine including CRISPR nanoparticle, exosomes for the treatment of BC/TNBC and other molecular targets available such as poly (ADP-ribose) polymerase (PARP), epidermal growth factor receptor (EGFR), Vascular endothelial growth factor (VEGF), etc. for further exploration have been discussed.

TL;DR: A membrane-coated laser-responsive shape changeable nanomedicine, I-P@NPs@M, shows the best antitumor effect, resulting in 85.80% suppression of breast cancer in mice model, and also remarkably inhibits lung metastasis.

TL;DR: The synergism of the PTT and immunotherapy inhibited tumor growth, metastasis and recurrence, which resulted in potent anticancer therapeutic effects with few side effect.

TL;DR: The contributions of the structure and composition of OMV to their applications are analyzed, the methods used to isolate and characterize OMVs are summarized, and recent progress and future perspectives of OMVs in biomedical applications are highlighted.

TL;DR: The results of this study of release mechanisms should provide a basis for adjustments of drug release dosage and duration, thereby contributing to the development of drug delivery systems satisfying clinical requirements.

TL;DR: A smart pH- and reactive oxygen species (ROS)-responsive injectable hydrogel with self-healing and remodeling capability was designed and showed good biocompatibility, and greatly promoted the healing of infected wounds in vitro by cell scratch assay.

TL;DR: A wide variety of strategies for accelerating wound healing are discussed; from systemic or local dressing-free therapies, to cell-free dressings including films, biopolymeric porous scaffolds, electrospun nanofiber meshes and hydrogels.

TL;DR: The role and application of NLC is described in detail, along with its different fabrication techniques and associated limitations, for brain targeting of bioactives with particular reference to its surface modifications, formulations aspects, pharmacokinetic behavior and efficacy towards the treatment of various neurological disorders.

TL;DR: This work intends to outline the latest advances in ferroptosis-driven cancer nanotherapeutics at the intersection of ferroPTosis and bionanotechnology and highlight the future expectations and challenges.

TL;DR: A self-sufficient bi-prodrug nanomedicine strategy was reported to realize a minimalist drug nanoplatform for strengthening immunotherapeutic capability in chemotherapy through its self-owned functions.

TL;DR: The therapeutic strategy of using ultrasound for improved drug delivery with a special focus on cancer therapy and sonoporation has been shown to be a highly effective method to improve drug uptake through microbubble potentiated enhancement of microvascular permeability.

TL;DR: Well-characterized astrocyte-derived EVs (ADEVs) generated in specific culture conditions and ADEVs that are engineered to carry the desired miRNAs or proteins are likely useful for treating brain injury and neurogenerative diseases.

TL;DR: Agarose is a prominent marine polysaccharide representing reversible thermogelling behavior, outstanding mechanical properties, high bioactivity, and switchable chemical reactivity for functionalization, which has received particular attention in the fabrication of advanced delivery systems as sophisticated carriers for therapeutic agents.

TL;DR: Intravital imaging revealed that monomeric Nbs very quickly and homogenously distribute through tumour tissue, at a rate significantly greater than dimeric Nbs and mAbs, which underlines the potential of monomersic Nb tracers and therapeutics in molecular imaging and targeted therapies.

TL;DR: Based on an in vivo assessment of the healing process through a full-thickness skin defect model, the controlled EGF release from a supramolecular hydrogel exhibited superior wound healing efficiency with respect to granulation tissue formation, growth factor levels, and angiogenesis.

TL;DR: The article is aimed to gather all the information of the past 10 years related to the development and application of stimuli-responsive in situ nasal gel for brain drug delivery.

TL;DR: Overall, these nanoparticle-hydrogel superstructures hold significant clinical potential, and it is envisioned that future development along these lines will lead to unique solutions for addressing areas of pressing medical need.