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Xin Duan
Researcher at Peking Union Medical College
Publications - 12
Citations - 185
Xin Duan is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Pulmonary hypertension & Medicine. The author has an hindex of 4, co-authored 9 publications receiving 97 citations.
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Journal ArticleDOI
Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs
Jian Wang,Xin Fu,Kai Yang,Qian Jiang,Yuqin Chen,Jing Jia,Xin Duan,Elizabeth Wenqian Wang,Jianxing He,Pixin Ran,Nanshan Zhong,Gregg L. Semenza,Wenju Lu,Wenju Lu +13 more
TL;DR: BMP4 acts downstream of HIF-1 and mediates hypoxia-induced up-regulation of TRPC, leading to increased basal [Ca(2+)]i in PASMCs, promoting CHPH pathogenesis.
Journal ArticleDOI
Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients
Jing Liao,Wenju Lu,Yuqin Chen,Xin Duan,Chenting Zhang,Xiaoyun Luo,Ziying Lin,Jiyuan Chen,Jiyuan Chen,Shiyun Liu,Han Yan,Yilin Chen,Huazhuo Feng,Dansha Zhou,Xu Chen,Zizhou Zhang,Qifeng Yang,Xinyi Liu,Haiyang Tang,Jing Li,Ayako Makino,Jason X.-J. Yuan,Nanshan Zhong,Kai Yang,Jian Wang,Jian Wang +25 more
Journal ArticleDOI
Bone morphogenetic protein 2 decreases TRPC expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells
Yi Zhang,Wenju Lu,Kai Yang,Kai Yang,Lei Xu,Lei Xu,Ning Lai,Ning Lai,Lichun Tian,Qian Jiang,Xin Duan,Minsheng Chen,Jian Wang,Jian Wang +13 more
TL;DR: Results indicate that BMP2 participates in regulating Ca(2+) signaling in PASMCs by inhibiting TRPC1, TRPC4, and TRPC6 expression, thus leading to reduced SOCE and basal [Ca(2+)]i and inhibition of cell proliferation and migration.
Journal ArticleDOI
Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension
Yuqin Chen,Wenju Lu,Kai Yang,Xin Duan,Mengxi Li,Xiuqing Chen,Jie Zhang,Meidan Kuang,Shiyun Liu,Xiongting Wu,Guofa Zou,Chunli Liu,Cheng Hong,Wenjun He,Jing Liao,Chi Hou,Zhe Zhang,Qiuyu Zheng,Jiyuan Chen,Nuofu Zhang,Haiyang Tang,Haiyang Tang,Rebecca Vanderpool,Ankit A. Desai,Franz Rischard,Stephen M. Black,Joe G.N. Garcia,Ayako Makino,Jason X.-J. Yuan,Nanshan Zhong,Jian Wang,Jian Wang +31 more
TL;DR: Tetramethylpyrazine was originally isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto and has since been synthesized and has a long history of beneficial effects in the treatment of many cardiovascular diseases.
Journal ArticleDOI
Bortezomib alleviates experimental pulmonary hypertension by regulating intracellular calcium homeostasis in PASMCs.
Jun Zhang,Wenju Lu,Yuqin Chen,Qian Jiang,Kai Yang,Meichan Li,Ziyi Wang,Xin Duan,Lei Xu,Haiyang Tang,Dejun Sun,Jian Wang +11 more
TL;DR: Results indicate that BTZ exerts its protective role in the development of PH potentially by inhibiting the canonical transient receptor potential-SOCE-[Ca(2+)]i signaling axis in PASMCs.