Xin Ku

TL;DR: Results about the mechanisms involved in the anticancer activities of thiosemicarbazones will aid in the rational design of novel topoisomerase II-targeted drugs and will provide insights into the discovery and development of novel cancer therapeutics based on the dual activity to chelate iron and to inhibit the catalytic activity of topoisomersase IIalpha.

TL;DR: This paper presents ChemMapper, an online platform to predict polypharmacology effect and mode of action for small molecules based on 3D similarity computation, which is designed to provide versatile services in a variety of chemogenomics, drug repurposing, polyph pharmacology, novel bioactive compounds identification and scaffold hopping studies.

TL;DR: The optimization of the kinobead assay is reported resulting in the combination of five chemical probes and four cell lines to cover half the human kinome in a single assay (∼ 260 kinases).

TL;DR: The versatility, air-stability, operational simplicity, and operational simplicity of this protocol, in addition to the higher yields and shorter reaction time it provides, highlight the potential of using this method in large scale library synthesis involving carbon-heteroatom formation.

TL;DR: The in vivo antitumor efficacy study demonstrated that compound 3x significantly inhibited tumor growth and induced tumor stasis in an EGFR-T790M/L858R-driven human nonsmall-cell lung cancer xenograft mouse model.