L
Liping Lin
Researcher at Chinese Academy of Sciences
Publications - 71
Citations - 3162
Liping Lin is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Angiogenesis & Tyrosine kinase. The author has an hindex of 33, co-authored 68 publications receiving 2948 citations. Previous affiliations of Liping Lin include Sinopec.
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The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma
TL;DR: Results implied that this targeted nanocarrier of docetaxel could enhance its antitumor effect in vivo with low systemic toxicity for the treatment of locally advanced and metastatic HCC.
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Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential.
TL;DR: Quercetin has antiangiogenic potential and that this effect may be related to an influence on the expression and activity of matrix metalloproteinase-2, which is involved in the angiogenic process of migration, invasion, and tube formation.
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A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity
He Huang,Qin Chen,Xin Ku,Linghua Meng,Liping Lin,Xiang Wang,Caihua Zhu,Yi Wang,Zhi Chen,Ming Li,Hualiang Jiang,Kaixian Chen,Jian Ding,Hong Liu +13 more
TL;DR: Results about the mechanisms involved in the anticancer activities of thiosemicarbazones will aid in the rational design of novel topoisomerase II-targeted drugs and will provide insights into the discovery and development of novel cancer therapeutics based on the dual activity to chelate iron and to inhibit the catalytic activity of topoisomersase IIalpha.
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PE, a new sulfated saponin from sea cucumber, Exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo
Fang Tian,Zhang Xiongwen,Yungyuang Tong,Yang-Hua Yi,Shi-Long Zhang,Ling Li,Peng Sun,Liping Lin,Jian Ding +8 more
TL;DR: In vitro and in vivo anti-angiogenic activity associated with inhibition of VEGFR2 signaling, and an anti-tumorActivity associated with decreased proliferation of tumor cells and increased apoptosis of both endothelial cells and tumor cells are indicated.
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Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species.
TL;DR: DHA inhibited the proliferation of a panel of tumor cells originated from different tissue types and uncovered that DHA induces apoptosis is dependent of iron and p38 MAPK activation but not ROS in HL-60 cells.