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Xin Li
Researcher at University of Cambridge
Publications - 25
Citations - 368
Xin Li is an academic researcher from University of Cambridge. The author has contributed to research in topics: Mass spectrometry & Chemistry. The author has an hindex of 10, co-authored 21 publications receiving 298 citations. Previous affiliations of Xin Li include GlaxoSmithKline & University of Queensland.
Papers
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Journal ArticleDOI
Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms.
Jelena Trmcic-Cvitas,Erol Hasan,Madeleine Ramstedt,Xin Li,Mark E. Cooper,Chris Abell,Wilhelm T.S. Huck,Julien E. Gautrot +7 more
TL;DR: Evidence that large macromolecules cannot infiltrate dense polymer brushes and that bulky antibody recognition occurs in the upper part of these coatings is found.
Journal ArticleDOI
Sensitive, High Throughput Detection of Proteins in Individual, Surfactant-Stabilized Picoliter Droplets Using Nanoelectrospray Ionization Mass Spectrometry
Clive A. Smith,Xin Li,Todd H. Mize,Timothy Sharpe,Edmund I. Graziani,Chris Abell,Wilhelm T. S. Huck +6 more
TL;DR: In this article, electrospray ionization mass spectrometry (ESI-MS) was used to measure femtomole quantities of proteins in individual pico-to nanoliter droplets.
Journal ArticleDOI
Coupling Droplet Microfluidics with Mass Spectrometry for Ultrahigh-Throughput Analysis of Complex Mixtures up to and above 30 Hz.
Emily E Kempa,Clive A. Smith,Xin Li,Bruno Bellina,Keith Richardson,Steven Derek Pringle,James L. Galman,Nicholas J. Turner,Perdita E. Barran +8 more
TL;DR: Mass spectrometry readily provides chemical identity and abundance for complex mixtures, and here, microdroplet generation microfluidics is used to supply picoliter aliquots for analysis at rates up to and including 33 Hz.
Journal ArticleDOI
Measurement of drug lipophilicity and pKa using acoustics.
Xin Li,Mark E. Cooper +1 more
TL;DR: This work investigated an alternate approach to lipophilicity determination using a mimic of an alkyl alcohol with compound partitioning quantified using acoustic sensing to determine weakly acidic drug pK(a) by profiling log D changes during pH titration.
Journal ArticleDOI
Cyto-Mine: An Integrated, Picodroplet System for High-Throughput Single-Cell Analysis, Sorting, Dispensing, and Monoclonality Assurance.
Dimitris Josephides,Davoli Serena A,William Whitley,Raphael Ruis,Robert Salter,Sinan Gokkaya,Maeva Vallet,Darren Matthews,Giuseppe Benazzi,Elena Shvets,Frank Gesellchen,Drew Geere,Liu Xin,Xin Li,Benedict Mackworth,William F. Young,Zachary Owen,Clive A. Smith,Dale Starkie,James White,Bernie Sweeney,Matthew Hinchliffe,Simon Peter Tickle,Daniel John Lightwood,Rehak Marian,Craig Frank F,David R. Holmes +26 more
TL;DR: The novel Cyto-Mine Single Cell Analysis and Monoclonality Assurance System overcomes the limitations of current technologies by screening hundreds of thousands of individual cells for secreted target proteins, and then isolating and dispensing the highest producers into microtiter plate wells (MTP).