Xin Ni

TL;DR: This study suggests that estrogen deficiency results in NLRP3 inflammasome activation, thereby leading to neuroinflammation in hippocampus and depression and anxiety.

TL;DR: Swimming exercise may inhibit activation of inflammation/IDO pathways induced by CUMS, thereby ameliorating depression and suggested that CUMS activate HPA axis and induce immune activation, which may stimulate IDO activity, leading to the reduction of 5-HT level in brain, thereby resulting in depression.

TL;DR: Inhibition of H2S and NO production may be a mechanism by which glucocorticoids coordinate the balance between pro- and anti-inflammatory mediators during inflammation, besides the NO-dependent way.

TL;DR: It was found that silencing of Sirt1 abolished the protective effect of miR-22 inhibitor against H/R-induced mitochondrial dysfunction and cell injury in cardiomyocytes, and this discovery reveals a novel molecular mechanism for cardiac mitochondrial dysfunction during myocardial I/R injury at the miRNA level.

TL;DR: This study established FGSC lines from scarce ovarian cortical tissues that exist in follicular aspirates (faFGSCs), which are produced and discarded in in vitro fertilization centers worldwide and developed a strategy guiding FGSCs differentiated into germinal vesicle (GV) stage oocytes in vitro and revealed their developmental mechanisms.