Xin-Yan Li

TL;DR: Spinal DAO mediates both induction and maintenance of formalin-induced tonic pain and further validate spinal DAO as a novel and efficacious target molecule for the treatment of chronic pain.

TL;DR: It is reported that intrathecal IL-10 injection dose dependently attenuated mechanical allodynia and thermal hyperalgesiain male and female neuropathic rats, and revealed that IL- 10 produced antinociception through spinal microglial β-endorphin expression, but not inhibition of neuro inflammation.

TL;DR: This study demonstrates that USP 5 plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein, and provides a rationale for USP5 being a potential therapeutic approach against PDAC.

TL;DR: It is suggested that lappaconitine exhibits antinociception through directly stimulating spinal microglial dynorphin A expression in neuropathic rats, and in primary cultures of microglia but not neurons or astrocytes.

TL;DR: It is illustrated that cinobufagin produces mechanical antiallodynia in bone cancer pain through spinal microglial expression of IL-10 and subsequent β-endorphin following activation of α7-nAChRs, which highlights the broad significance of the recently uncovered spinal micro Glaxo-10/β- endorphin pathway in antinociception.