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Xin-Yan Li
Researcher at Shanghai Jiao Tong University
Publications - 26
Citations - 483
Xin-Yan Li is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Nociception & Neuropathic pain. The author has an hindex of 13, co-authored 23 publications receiving 374 citations.
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A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.
TL;DR: Spinal DAO mediates both induction and maintenance of formalin-induced tonic pain and further validate spinal DAO as a novel and efficacious target molecule for the treatment of chronic pain.
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Spinal interleukin-10 produces antinociception in neuropathy through microglial β-endorphin expression, separated from antineuroinflammation.
Hai-Yun Wu,Xiao-Fang Mao,Xue-Qi Tang,Usman Ali,Evhy Apryani,Hao Liu,Xin-Yan Li,Yong-Xiang Wang +7 more
TL;DR: It is reported that intrathecal IL-10 injection dose dependently attenuated mechanical allodynia and thermal hyperalgesiain male and female neuropathic rats, and revealed that IL- 10 produced antinociception through spinal microglial β-endorphin expression, but not inhibition of neuro inflammation.
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USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein.
TL;DR: This study demonstrates that USP 5 plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein, and provides a rationale for USP5 being a potential therapeutic approach against PDAC.
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Lappaconitine, a C18-diterpenoid alkaloid, exhibits antihypersensitivity in chronic pain through stimulation of spinal dynorphin A expression.
TL;DR: It is suggested that lappaconitine exhibits antinociception through directly stimulating spinal microglial dynorphin A expression in neuropathic rats, and in primary cultures of microglia but not neurons or astrocytes.
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The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors.
Evhy Apryani,Usman Ali,Zi-Ying Wang,Hai-Yun Wu,Xiao-Fang Mao,Khalil Ali Ahmad,Xin-Yan Li,Yong-Xiang Wang +7 more
TL;DR: It is illustrated that cinobufagin produces mechanical antiallodynia in bone cancer pain through spinal microglial expression of IL-10 and subsequent β-endorphin following activation of α7-nAChRs, which highlights the broad significance of the recently uncovered spinal micro Glaxo-10/β- endorphin pathway in antinociception.