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Xin Zhou
Researcher at Tianjin Medical University General Hospital
Publications - 107
Citations - 3280
Xin Zhou is an academic researcher from Tianjin Medical University General Hospital. The author has contributed to research in topics: Medicine & Ventricular remodeling. The author has an hindex of 24, co-authored 91 publications receiving 2510 citations. Previous affiliations of Xin Zhou include Tianjin Medical University.
Papers
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Journal ArticleDOI
Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance.
Zhaokang Cheng,Lailiang Ou,Xin Zhou,Fei Li,Xiaohua Jia,Yinguo Zhang,Xiaolei Liu,Yu-Ming Li,Christopher A. Ward,Luis G. Melo,Deling Kong +10 more
TL;DR: In this paper, the authors evaluated the efficacy of intravenous infusion of genetically modified mesenchymal stem cells (MSCs) overexpressing CXC chemokine receptor 4 (CXCR4).
Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance
TL;DR: In summary, intravenous delivery of genetically modified MSCs expressing CXCR4 may be a useful, non-invasive, and safe therapeutic strategy for post-infarction myocardial repair.
Journal ArticleDOI
Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients.
Xiao Cui,Lei Ye,Jing Li,Ling Jin,Wenjie Wang,Shuangyue Li,Minghui Bao,Shouling Wu,Lifeng Li,Bin Geng,Xin Zhou,Jian Zhang,Jun Cai +12 more
TL;DR: It is found that CHF was associated with distinct gut microbiota dysbiosis and pinpointed the specific core bacteria imbalance in CHF, along with correlations between changes in certain metabolites and gut microbes.
Journal ArticleDOI
Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction
Xin Zhou,Jing Li,Junli Guo,Bin Geng,Wen-Jie Ji,Qian Zhao,Jinlong Li,Xin-Lin Liu,Jun-Xiang Liu,Zhao-Zeng Guo,Wei Cai,Yongqiang Ma,Dong Ren,Jun Miao,Shao-Bo Chen,Zhuoli Zhang,Junru Chen,Jiuchang Zhong,Wenbin Liu,Minghui Zou,Yu-Ming Li,Jun Cai +21 more
TL;DR: These results provide the first evidence that cardiovascular outcomes post-MI are driven by intestinal microbiota translocation into systemic circulation and new therapeutic strategies targeting to protect the gut barrier and eliminate gut bacteria translocation may reduce or even prevent cardiovascular events post- MI.
Journal ArticleDOI
Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy
Lan Ge,Xin Zhou,Wen-Jie Ji,Rui-Yi Lu,Yan Zhang,Yi-Dan Zhang,Yongqiang Ma,Ji-Hong Zhao,Yu-Ming Li +8 more
TL;DR: Evidence is provided for the existence of NETs in I/R-challenged myocardium and the long-term benefit of a novel DNase-based reperfusion strategy (DNase I + rt-PA) is confirmed, which might be a promising option for the treatment of myocardial I-R injury and coronary no-reflow.