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Xinghuo Wu
Researcher at Huazhong University of Science and Technology
Publications - 88
Citations - 2197
Xinghuo Wu is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Autophagy. The author has an hindex of 18, co-authored 75 publications receiving 1095 citations.
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Journal ArticleDOI
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo
Zhiwei Liao,Rongjin Luo,Gaocai Li,Yu Song,Shengfeng Zhan,Kangcheng Zhao,Wenbin Hua,Yukun Zhang,Xinghuo Wu,Cao Yang +9 more
TL;DR: This work is the first to demonstrate that MSC-exos could modulate ER stress-induced apoptosis during AGEs-associated IVD degeneration, and highlight the therapeutic effects of exosomes in preventing IDD progression.
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Wearable Health Devices in Health Care: Narrative Systematic Review
TL;DR: The review shows that the wearable medical devices developed so far have been designed for use on all parts of the human body, including the head, limbs, and torso, and predicts that with the development of science and technology and the popularization of personalized health concepts, wearable devices will play a greater role in the field of health care and become better integrated into people’s daily lives.
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Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.
Yu Song,Shuai Li,Wen Geng,Rongjin Luo,Wei Liu,Ji Tu,Kun Wang,Liang Kang,Huipeng Yin,Xinghuo Wu,Yong Gao,Yukun Zhang,Cao Yang +12 more
TL;DR: It is confirmed that SIRT3 protects against AGEs-induced human NP cell apoptosis and IVD degeneration, and Targeting Sirtuin3 to improve mitochondrial redox homeostasis may represent a potential therapeutic strategy for attenuating A GEs-associated IVd degeneration.
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TNF-a mediated inflammatory macrophage polarization contributes to the pathogenesis of steroid-induced osteonecrosis in mice.
Xinghuo Wu,Weihua Xu,Xiaobo Feng,Yu He,Xianzhe Liu,Yong Gao,Shuhua Yang,Zengwu Shao,Cao Yang,Zhewei Ye +9 more
TL;DR: It was showed that TNF-a-mediated alteration of M1/M2 macrophage polarization contributed to the pathogenesis of steroid-induced osteonecrosis and could be beneficial for resolving inflammation and promoting tissue repair.
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Wear performance of ultrahigh molecular weight polyethylene/quartz composites.
TL;DR: The results showed that organosiloxane can act as a cross-linking agent for UHMWPE matrix and serve as a coupling agent for improving the bonding between the quartz particles and the UH MWPE matrix.